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Immune Homeostasis pp 81–106Cite as

Homeostatic Proliferation of Mature T Cells

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 979))

Abstract

Under normal circumstances, the secondary lymphoid tissues contain a predictable number of T cells with a diverse T cell receptor (TCR) repertoire. Such a T cell pool must be of sufficient size to confer maximum protection of the host from infectious pathogens and cancer, but small enough not to overburden the host. The T cell pool is maintained by a combination of de novo T cell production by the thymus and by the long-term survival and gradual turnover of mature T cells in the periphery. The latter process, termed homeostatic proliferation, has been intensely investigated over the past 20 years, and a few techniques have been developed to facilitate these studies. In this chapter, we describe the experimental procedures that allow conspicuous visualization of homeostatic proliferation, which have been instrumental in facilitating recent advances in the study of T cell homeostasis.

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Author information

Authors and Affiliations

  1. Doctoral Program in Chemical and Biological Sciences, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA, USA

    Christopher E. Martin, Kwesi Frimpong-Boateng & Darina S. Spasova

  2. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA

    Christopher E. Martin, Kwesi Frimpong-Boateng, Darina S. Spasova & John C. Stone

  3. Academy of Immunology and Microbiology (AIM), Institute of Basic Science (IBS) Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea

    Charles D. Surh

Authors
  1. Christopher E. Martin
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  2. Kwesi Frimpong-Boateng
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  3. Darina S. Spasova
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  4. John C. Stone
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  5. Charles D. Surh
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Corresponding author

Correspondence to Charles D. Surh .

Editor information

Editors and Affiliations

  1. of the Health Sciences, Department of Pharmacology, Uniformed Services University, Jones Bridge Road 4301, Bethesda, 20814, Maryland, USA

    Andrew L. Snow

  2. NIAID, Laboratory of Immunology, National Institutes of Health, Rockville Pike 9000, Bethesda, 20892, Maryland, USA

    Michael J. Lenardo

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Martin, C.E., Frimpong-Boateng, K., Spasova, D.S., Stone, J.C., Surh, C.D. (2013). Homeostatic Proliferation of Mature T Cells. In: Snow, A., Lenardo, M. (eds) Immune Homeostasis. Methods in Molecular Biology, vol 979. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-290-2_9

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  • DOI: https://doi.org/10.1007/978-1-62703-290-2_9

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-289-6

  • Online ISBN: 978-1-62703-290-2

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