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Enantioseparations by Thin-Layer Chromatography

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Book cover Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 970))

Abstract

An up-to-date overview of thin-layer chromatography (TLC) techniques for chiral separations of various significant and/or recent examples of enantioresolutions is reported. Furthermore, examples for chiral separations obtained on achiral commercially available C18 TLC plates are described in detail. These include the enantioseparation of methylthiohydantoin-phenylalanine and methylthiohydantoin-tyrosine using hydroxyethyl-β-cyclodextrin as mobile phase additive and the separation of the enantiomers of warfarin and p-chlorowarfarin using bovine serum albumin as mobile phase additive.

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Authors and Affiliations

  1. Department of Chemistry, University of Florence, Sesto Fiorentino, Italy

    Massimo Del Bubba, Leonardo Checchini, Alessandra Cincinelli & Luciano Lepri

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  1. Massimo Del Bubba
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  2. Leonardo Checchini
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  3. Alessandra Cincinelli
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  4. Luciano Lepri
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Correspondence to Massimo Del Bubba .

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Editors and Affiliations

  1. , Department of Pharmaceutical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, Jena, 07743, Germany

    Gerhard K. E. Scriba

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Del Bubba, M., Checchini, L., Cincinelli, A., Lepri, L. (2013). Enantioseparations by Thin-Layer Chromatography. In: Scriba, G. (eds) Chiral Separations. Methods in Molecular Biology, vol 970. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-263-6_2

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  • DOI: https://doi.org/10.1007/978-1-62703-263-6_2

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