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Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins

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Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 970))

Abstract

The enantioseparation of acidic and basic compounds can be successfully achieved in nonaqueous capillary electrophoresis using single-isomer charged β-cyclodextrin (β-CD) derivatives of opposite charge to that of the analytes. This chapter describes how to separate the enantiomers of three basic substances selected as model compounds, i.e., alprenolol, bupranolol, and terbutaline, using the negatively charged heptakis(2,3-di-O-acetyl-6-O-sulfo)-β-CD. The enantiomers of three acidic drugs (tiaprofenic acid, suprofen, and flurbiprofen) are resolved using a monosubstituted amino β-CD derivative, namely, 6-monodeoxy-6-mono(3-hydroxy)propylamino-β-CD.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Liège, Liège, Belgium

    Anne-Catherine Servais & Marianne Fillet

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  1. Anne-Catherine Servais
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  2. Marianne Fillet
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Correspondence to Anne-Catherine Servais .

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Editors and Affiliations

  1. , Department of Pharmaceutical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, Jena, 07743, Germany

    Gerhard K. E. Scriba

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Servais, AC., Fillet, M. (2013). Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins. In: Scriba, G. (eds) Chiral Separations. Methods in Molecular Biology, vol 970. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-263-6_19

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  • DOI: https://doi.org/10.1007/978-1-62703-263-6_19

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-262-9

  • Online ISBN: 978-1-62703-263-6

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