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Enantioseparations by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

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Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 970))

Abstract

Due to their commercial availability, cyclodextrins are the most frequently used chiral selectors in capillary electrophoresis as documented by the numerous publications in the field. A variety of migration modes can be realized depending on the characteristics of the cyclodextrins and the analytes. The basic considerations regarding the development of a chiral CE method employing cyclodextrins as chiral selectors are briefly discussed. The presented examples illustrate the separation modes of an acidic and a basic analyte with native and charged cyclodextrin derivatives as a function of the pH of the background electrolyte and the cyclodextrin concentration.

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Authors and Affiliations

  1. Department of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University Jena, Jena, Germany

    Gerhard K. E. Scriba & Pavel Jáč

Authors
  1. Gerhard K. E. Scriba
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  2. Pavel Jáč
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Correspondence to Gerhard K. E. Scriba .

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Editors and Affiliations

  1. , Department of Pharmaceutical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, Jena, 07743, Germany

    Gerhard K. E. Scriba

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Scriba, G.K.E., Jáč, P. (2013). Enantioseparations by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors. In: Scriba, G. (eds) Chiral Separations. Methods in Molecular Biology, vol 970. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-263-6_17

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  • DOI: https://doi.org/10.1007/978-1-62703-263-6_17

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-262-9

  • Online ISBN: 978-1-62703-263-6

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