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Sensible Use of High-Sensitivity Troponin Assays

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Calcium-Binding Proteins and RAGE

Part of the book series: Methods in Molecular Biology ((MIMB,volume 963))

Abstract

The first intracellular Ca2+-sensor protein to be described was the troponin complex. Only later it was ­discovered that cardiac-specific isoforms of troponin I (cTnI) and troponin T (cTnT) exist, and nowadays, measurement of cardiac troponins is a corner stone in the diagnosis of patients with acute coronary syndrome (ACS). High-sensitivity (hs-) assays have been developed that can record slightly elevated plasma concentrations of cardiac troponins as early as 3 h after onset of clinical symptoms. International guidelines defined a diagnostic cut-off at cardiac troponin levels corresponding to the 99th percentile of a healthy reference population and require that hs-assays measure this concentration with an interassay coefficient of variation ≤10%. This review provides an overview of the diagnostic and prognostic use of cardiac troponins.

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Authors and Affiliations

  1. Institute for Clinical Chemistry, University Hospital Zürich, Zürich, Switzerland

    Danielle Hof & Arnold von Eckardstein

  2. Department of Cardiology/Cardiovascular Research, University Hospital Zürich, Zürich, Switzerland

    Roland Klingenberg

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  1. Danielle Hof
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  2. Roland Klingenberg
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Correspondence to Arnold von Eckardstein .

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  1. Div of Clinical Chem & Biochem, Department of Pediatrics, University of Zürich, Steinwiesstrasse 75, Zürich, 8032, Switzerland

    Claus W. Heizmann

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Hof, D., Klingenberg, R., von Eckardstein, A. (2013). Sensible Use of High-Sensitivity Troponin Assays. In: Heizmann, C. (eds) Calcium-Binding Proteins and RAGE. Methods in Molecular Biology, vol 963. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-230-8_24

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  • DOI: https://doi.org/10.1007/978-1-62703-230-8_24

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