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Peroxisome Proliferator-Activated Receptors (PPARs) pp 325–336Cite as

Behavioral Paradigms to Evaluate PPAR Modulation in Animal Models of Brain Injury

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 952))

Abstract

The use of behavioral testing has become an invaluable tool for assessing the efficacy of therapeutics for a variety of disorders of the central nervous system. This chapter will describe in detail several behavioral paradigms to evaluate the efficacy of PPAR agonists to modulate cognitive impairments in rodent models. When used together as a battery these procedures allow for a global assessment of cognition. These tests are explained in detail below, and include: (1) Novel Object Recognition (NOR), (2) Morris Water Maze (MWM), (3) Delay Match to Place (DMP), and (4) Cue Strategy.

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Acknowledgments

Supported by National Institutes of Health grants CA112593 and CA113267.

Author information

Authors and Affiliations

  1. Departments of Radiation Oncology and Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Dana Greene-Schloesser

  2. Department of Cancer Biology and Brain Tumor Center of Excellence, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Caroline I. Schnegg

  3. Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Mike E. Robbins

Authors
  1. Dana Greene-Schloesser
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  2. Caroline I. Schnegg
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  3. Mike E. Robbins
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Corresponding author

Correspondence to Mike E. Robbins .

Editor information

Editors and Affiliations

  1. School of Pharmacy, University of Missouri-Kansas City, Charlotte Street 2464, Kansas City, 64108, USA

    Mostafa Z. Badr

  2. School of Pharmacy, University of Missouri-Kansas City, Charlotte Street 2464, Kansas City, 64108, Missouri, USA

    Jihan A. Youssef

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Greene-Schloesser, D., Schnegg, C.I., Robbins, M.E. (2013). Behavioral Paradigms to Evaluate PPAR Modulation in Animal Models of Brain Injury. In: Badr, M., Youssef, J. (eds) Peroxisome Proliferator-Activated Receptors (PPARs). Methods in Molecular Biology, vol 952. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-155-4_24

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  • DOI: https://doi.org/10.1007/978-1-62703-155-4_24

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-154-7

  • Online ISBN: 978-1-62703-155-4

  • eBook Packages: Springer Protocols

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