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Teratogenicity Testing pp 243–253Cite as

Fetal Soft Tissue Examinations by Microdissection

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 947))

Abstract

This chapter describes methods for the examination of fetal abdominal and thoracic soft tissues by microdissection on either fresh (non-rodent) or fixed (rodent) specimens in order to detect structural abnormalities. With hundreds of fetuses examined for each species (rodent and non-rodent) in regulatory reproductive toxicity assessments (ICH, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Multidisciplinary/M3_R2/Step4/M3_R2__Guideline.pdf, 2009; ICH, http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Safety/S5_R2/Step4/S5_R2__Guideline.pdf, 2005), microdissection techniques allow a thorough and relatively rapid examination of fetuses for soft tissue abnormalities.

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References

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Acknowledgments

Thanks to the Fetal Pathology team of Ricerca Biosciences.

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Authors and Affiliations

  1. Ricerca Biosciences, Saint-Germain sur l’Arbresle, France

    Mariline Leroy & Audrey Jocteur-Monrozier

Authors
  1. Mariline Leroy
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  2. Audrey Jocteur-Monrozier
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Corresponding author

Correspondence to Mariline Leroy .

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Editors and Affiliations

  1. CiToxLAB, BP 563, Evreux, 27005, France

    Paul C. Barrow

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Leroy, M., Jocteur-Monrozier, A. (2013). Fetal Soft Tissue Examinations by Microdissection. In: Barrow, P. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 947. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-131-8_20

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  • DOI: https://doi.org/10.1007/978-1-62703-131-8_20

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-130-1

  • Online ISBN: 978-1-62703-131-8

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