Abstract
The minipig is a suitable species for regulatory teratology testing and may be regarded as an alternative to the rabbit, dog, and primate. The first successful regulatory teratology studies in the minipig were performed in the 1990s. It became clear that minipigs have several benefits over the other non-rodents, as they are purpose-bred for laboratory use, they are sexually mature at approximately 5 months of age, and they produce multiple offspring. The minipig has subsequently gained regulatory acceptance in the teratology testing of new drugs.
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Acknowledgment
Many thanks to CiToxLAB Scantox for providing the photographs of fetuses at the time of caesarean sections and fetal outcomes.
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McAnulty, P.A. (2013). Teratology Studies in the Minipig. In: Barrow, P. (eds) Teratogenicity Testing. Methods in Molecular Biology, vol 947. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-131-8_13
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DOI: https://doi.org/10.1007/978-1-62703-131-8_13
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