Abstract
Human and nonhuman primates are opportunistic feeders and are prone to both obesity and binge eating when food is abundant. This chapter describes procedures for studying binge eating using a foraging model that engenders large meals in nonhuman primates. Baboons have access to food 24 h each day, but they have to complete a two-phase operant procedure in order to obtain it. Responding on one lever during a 30-min “seeking” phase is required before they can start a “taking” phase, where responding on another lever will lead to food delivery, i.e., a meal. Three days per week, baboons received candy during the first meal, and then food pellet meals were available the remainder of the day. Initially we compared a chocolate sugar-coated candy (M&M’s®) to a jelly sugar-coated candy (Skittles®). All baboons ate as much candy in the single candy meal as they did food pellets throughout the remainder of the day. Five baboons developed an aberrant behavior when they had access to M&M’s® in that they began to suck the candy coating off and throw away the chocolate center. This behavior rarely occurred with Skittles®, and it never occurred with food pellets.
This procedure can also be used to determine the effects of pharmacological agents on binge eating. For example, we examined the effects of the serotonergic drug dexfenfluramine and the dopaminergic drug d-amphetamine on food and candy consumption by determining complete dose–response functions for each drug when given on days prior to when Skittles® were available for the first meal and on days when only food pellets were available. The two drugs had different behavioral profiles of action. Both drugs decreased candy and food pellet consumption, but had varying effects on the latency to the first meal. Amphetamine increased the latency to the first candy and food meal, while dexfenfluramine only increased the latency to the food pellet meal. Thus, periodic access to a highly palatable candy food engendered large amounts of candy consumption in a single meal by all baboons, providing a behavioral baseline for assessing the effects of manipulations on binge eating, as well as regular food consumption, in the same animals.
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References
Altmann J et al (1993) Body size and fatness of free-living baboons reflect food availability and activity levels. Am J Primatol 30:149–161
Knott CD (1998) Changes in orangutan caloric intake, energy balance, and ketones in response to fluctuating fruit availability. Int J Primatol 19:1061–1079
Klein DA, Walsh BT (2004) Eating disorders: clinical features and pathophysiology. Physiol Behav 81:359–374
American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, Revised 4th edn. American Psychiatric Association, Washington, DC
Corwin RL, Buda-Levin A (2004) Behavioral models of binge-type eating. Physiol Behav 82:123–130
Corwin RL (2004) Binge-type eating induced by limited access in rats does not require energy restriction on the previous day. Appetite 42:139–142
Corwin RL et al (1998) Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats. Physiol Behav 65:545–553
Dimitriou SG, Rice HB, Corwin RL (2000) Effects of limited access to a fat option on food intake and body composition in female rats. Int J Eat Disord 28:436–445
Fisher JO, Birch LL (1999) Restricting access to palatable foods affects children’s behavioral response, food selection, and intake. Am J Clin Nutr 69:1264–1272
Owen J (1980) Feeding strategy. The University of Chicago Press, Chicago
Collier GH (1983) Life in a closed economy: the ecology of learning and motivation, vol 3. Wiley, New York
Collier GH (1985) Satiety: an ecological perspective. Brain Res Bull 14:693–700
Milton K (1980) The foraging strategy of howler monkeys. Columbia University Press, New York
Kelleher R (1966) Conditioned reinforcement in second-order schedules. J Exp Anal Behav 9:475–485
Foltin RW (2006) “Tasting and wasting” behavior in non-human primates: aberrant behavior or normal behavior in “times of plenty”. Physiol Behav 89:587–597
Goldfein JA et al (1993) Eating behavior in binge eating disorder. Int J Eat Disord 14:427–431
Yanovski SZ et al (1992) Food selection and intake of obese women with binge-eating disorder. Am J Clin Nutr 56:975–980
Guertin TL (1999) Eating behavior of bulimics, self-identified binge eaters, and non–disordered individuals: what differentiates these populations? Clin Psychol Rev 19:1–23
Kaye WH et al (1992) Laboratory assessment of feeding behavior in bulimia nervosa and healthy women: methods for developing a human-feeding laboratory. Am J Clin Nutr 55:372–380
Weltzin TE et al (1991) Feeding patterns in bulimia nervosa. Biol Psychiatry 30:1093–1110
Grilo CM, Masheb RM, Wilson GT (2005) Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison. Biol Psychiatry 57:301–309
Blundell JE, Latham CJ, Leshem MB (1976) Differences between the anorexic actions of amphetamine and fenfluramine—possible effects on hunger and satiety. J Pharm Pharmacol 28:471–477
Halford JC et al (2007) Serotonergic drugs: effects on appetite expression and use for the treatment of obesity. Drugs 67:27–55
Blundell JE et al (1979) Structural analysis of the actions of amphetamine and fenfluramine on food intake and feeding behaviour in animals and in man. Curr Med Res Opin 6:34–54
Bisaga A, Danysz W, Foltin RW (2008) Antagonism of glutamatergic NMDA and mGluR5 receptors decreases consumption of food in baboon model of binge-eating disorder. Eur Neuropsychopharmacol 18:794–802
Foltin RW, Haney M (2007) Effects of the cannabinoid antagonist SR141716(rimonabant) and d-amphetamine on palatable food and food pellet intake in non-human primates. Pharmacol Biochem Behav 86:766–773
Collier G, Hirsch E, Hamlin P (1977) The operant revisited. In: Honig WK, Staddon JER (eds) Handbook of operant behavior. Prentice Hall, Englewood, NJ
Arce M et al (2010) Diet choice, cortisol reactivity, and emotional feeding in socially housed rhesus monkeys. Physiol Behav 101:446–455
Morgan D et al (2002) Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci 5:169–174
Acknowledgements
This research was supported by DA-04130 from The National Institute on Drug Abuse, MH-65024 from the National Institute on Mental Health, and approved by the New York State Psychiatric Institute Animal Care and Use Committee. The assistance of Jean Will, April Modranowski, Angel Ramirez, Mal Zawodna and Drs. Suzette Evans, Margaret Haney, Diane Klein and Mohamed Osman is gratefully acknowledged.
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Foltin, R.W. (2013). Modeling Binge Eating in Nonhuman Primates. In: Avena, N. (eds) Animal Models of Eating Disorders. Neuromethods, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-104-2_7
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DOI: https://doi.org/10.1007/978-1-62703-104-2_7
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