Skip to main content

Introduction: Anorexia and Undereating

  • Protocol
  • First Online:
Book cover Animal Models of Eating Disorders

Part of the book series: Neuromethods ((NM,volume 74))

  • 999 Accesses

Abstract

The eating disorder (ED) anorexia nervosa (AN) is a severe psychiatric disorder. Although the clinical diagnosis of AN has been recognized and included in the American Psychological Association’s Diagnostic and Statistical Manual since the 1980s, the cause of AN remains largely unclear. A number of elements are suggested to be involved in the development of AN, including genetic and contextual. The use of animal models in research efforts to determine the causes of AN and expand upon the existing knowledge concerning the effects of this disorder may lead to significant progress in both understanding and treating this harmful illness.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR, 4th edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  2. Kaye W, Strober M, Jimerson D (2004) The neurobiology of eating disorders. In: Smith DS, Nestler EJ (eds) The neurobiology of mental illness. Oxford Press, New York, pp 1112–1128

    Google Scholar 

  3. Naughton M, Mulrooney JB, Leonard BE (2000) A review of the role of serotonin receptors in psychiatric disorders. Hum Psycho­pharmacol 15:397–415

    Article  PubMed  CAS  Google Scholar 

  4. Schultz W (2002) Getting formal with dopamine and reward. Neuron 36:241–263

    Article  PubMed  CAS  Google Scholar 

  5. Bailer UF, Kaye WH (2003) A review of neuropeptide and neuroendocrine dysregulation in anorexia and bulimia nervosa. Curr Drug Targets CNS Neurol Disord 2:53–59

    Article  PubMed  CAS  Google Scholar 

  6. Rolls ET (2010) Taste, olfactory and food texture reward processing in the brain and obesity. Int J Obes (Lond) 35:550–561

    Article  Google Scholar 

  7. Kelley AE et al (2005) Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86:773–795

    Article  PubMed  CAS  Google Scholar 

  8. Carmichael ST, Price JL (1996) Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys. J Comp Neurol 371:179–207

    Article  PubMed  CAS  Google Scholar 

  9. Kelley AE, Berridge KC (2002) The neuroscience of natural rewards: relevance to addictive drugs. J Neurosci 22:3306–3311

    PubMed  CAS  Google Scholar 

  10. Frank GK et al (2005) Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride. Biol Psychiatry 58:908–912

    Article  PubMed  CAS  Google Scholar 

  11. Fladung AK et al (2010) A neural signature of anorexia nervosa in the ventral striatal reward system. Am J Psychiatry 167:206–212

    Article  PubMed  Google Scholar 

  12. Wagner A et al (2008) Altered insula response to taste stimuli in individuals recovered from restricting-type anorexia nervosa. Neuro­psychopharmacology 33:513–523

    Article  PubMed  Google Scholar 

  13. Wagner A et al (2007) Altered reward processing in women recovered from anorexia nervosa. Am J Psychiatry 164:1842–1849

    Article  PubMed  Google Scholar 

  14. Kaye WH, Fudge JL, Paulus M (2009) New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 10:573–584

    Article  PubMed  CAS  Google Scholar 

  15. Halmi KA (2009) Perplexities and provocations of eating disorders. J Child Psychol Psychiatry 50:163–169

    Article  PubMed  Google Scholar 

  16. Bulik CM (2005) Exploring the gene-environment nexus in eating disorders. J Psychiatry Neurosci 30:335–339

    PubMed  Google Scholar 

  17. Johnson PM, Kenny PJ (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13:635–641

    Article  PubMed  CAS  Google Scholar 

  18. Avena NM, Rada P, Hoebel BG (2008) Underweight rats have enhanced dopamine release and blunted acetylcholine response in the nucleus accumbens while bingeing on sucrose. Neuroscience 156:865–871

    Article  PubMed  CAS  Google Scholar 

  19. Aoki C et al (2012) Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor alpha4 and delta subunits at the plasma membrane of hippocampal CA1 spines. Synapse 66(5):391–407

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Guido K. W. Frank M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this protocol

Cite this protocol

Frank, G.K.W. (2013). Introduction: Anorexia and Undereating. In: Avena, N. (eds) Animal Models of Eating Disorders. Neuromethods, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-104-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-104-2_15

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-103-5

  • Online ISBN: 978-1-62703-104-2

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics