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Animal Models of Eating Disorders pp 193–200Cite as

Deep Brain Stimulation for the Treatment of Binge Eating: Mechanisms and Preclinical Models

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Part of the book series: Neuromethods ((NM,volume 74))

Abstract

The prevalence of obesity continues to rise despite advances in behavioral, pharmacological, and surgical treatments. This is likely in part due to the overabundance of highly caloric food, which has extremely rewarding properties associated with dopaminergic neurotransmission in the ventral striatum where the nucleus accumbens (NAc) is located. The NAc has been repeatedly implicated in reward-seeking disorders, including binge eating, a common feature of obesity. Altered expression of dopaminergic receptors in the NAc has been associated with binge eating both in animals and humans. The application of deep brain stimulation (DBS) to the NAc to suppress binge eating in mice may further implicate the dopamine system in aberrant eating behavior. Molecular, biochemical, and optogenetic studies of the mechanism of DBS may also shed light on future treatment strategies for binge eating. Furthermore, given that DBS is a commonly used surgical therapy for multiple neurological disorders, this work may also pave the way for expanding the application of DBS to obesity.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA

    Casey H. Halpern M.D.

  2. Department of Animal Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Mark Attiah

  3. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Tracy L. Bale PH.D.

Authors
  1. Casey H. Halpern M.D.
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  2. Mark Attiah
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  3. Tracy L. Bale PH.D.
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Corresponding author

Correspondence to Tracy L. Bale PH.D. .

Editor information

Editors and Affiliations

  1. College of Medicine, Department of Psychiatry, University of Florida, S. Newell Dr. 100, Gainesville, 32610, Florida, USA

    Nicole M. Avena

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Halpern, C.H., Attiah, M., Bale, T.L. (2013). Deep Brain Stimulation for the Treatment of Binge Eating: Mechanisms and Preclinical Models. In: Avena, N. (eds) Animal Models of Eating Disorders. Neuromethods, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-104-2_12

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  • DOI: https://doi.org/10.1007/978-1-62703-104-2_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-103-5

  • Online ISBN: 978-1-62703-104-2

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