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Psychosocial Job Stress and Immunity: A Systematic Review

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 934))

Abstract

The purpose of this review was to provide current knowledge about the possible association between psychosocial job stress and immune parameters in blood, saliva, and urine. Using bibliographic databases (PubMed, PsychINFO, Web of Science, Medline) and the snowball method, 56 studies were found. In general, exposure to psychosocial job stress (high job demands, low job control, high job strain, job dissatisfaction, high effort–reward imbalance, overcommitment, burnout, unemployment, organizational downsizing, economic recession) had a measurable impact on immune parameters (reduced NK cell activity, NK and T cell subsets, CD4+/CD8+ ratio, and increased inflammatory markers). The evidence supports that psychosocial job stresses are related to disrupted immune responses but further research is needed to demonstrate cause–effect relationships.

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Acknowledgements

The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the US National Institute for Occupational Safety and Health.

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  1. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA

    Akinori Nakata

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  1. Akinori Nakata
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Correspondence to Akinori Nakata .

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  1. PharmTao, Lafayette St 4601, Santa Clara, 95056, California, USA

    Qing Yan

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Nakata, A. (2012). Psychosocial Job Stress and Immunity: A Systematic Review. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 934. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-071-7_3

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  • DOI: https://doi.org/10.1007/978-1-62703-071-7_3

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-070-0

  • Online ISBN: 978-1-62703-071-7

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