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Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates

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Animal Models in Diabetes Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 933))

Abstract

Nonhuman primates provide the ideal animal model for discovering and examining further the mechanisms underlying human type 2 diabetes mellitus. In all aspects studied to date the nonhuman primate has been shown to develop the same disease with the same features that develop in overweight middle-aged humans. This includes the progressive development of the known complications of diabetes, all of which are extraordinarily like those identified in humans. In addition, for the development and evaluation of new therapeutic agents, the translation of findings from nonhuman primates to application in humans has been highly predictable. Both therapeutic efficacy and identification of potential adverse responses can be effectively examined in nonhuman primates due to their great similarity to humans at the molecular, biochemical, and physiological levels. This chapter provides guidance for the development and management of a colony of monkeys with naturally occurring type 2 diabetes mellitus.

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Acknowledgments

This work was supported by NIH grants and contracts including NIA HHSN253200800C and NIA N01AG31012 and by past support from various foundations and industry. The extraordinary quality of care was based on the work of Drs. Noni Bodkin, Heidi Ortmeyer, and Cathy Kai-Lin Jen. The work on the complications of diabetes has had many critical collaborators and coworkers, ­particularly the dedicated efforts of Dr. Xenia Tigno.

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Authors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of South Florida, Tampa, FL, USA

    Barbara C. Hansen

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  1. Barbara C. Hansen
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Correspondence to Barbara C. Hansen .

Editor information

Editors and Affiliations

  1. , Department of Pharmacology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Hans-Georg Joost

  2. German Diabetes Centre, Clinical Biochemistry &Pathobiochemistry, Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, Düsseldorf, 40225, Germany

    Hadi Al-Hasani

  3. , Department of Experimental Diabetology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany

    Annette Schürmann

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Hansen, B.C. (2012). Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates. In: Joost, HG., Al-Hasani, H., Schürmann, A. (eds) Animal Models in Diabetes Research. Methods in Molecular Biology, vol 933. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-068-7_11

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  • DOI: https://doi.org/10.1007/978-1-62703-068-7_11

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-067-0

  • Online ISBN: 978-1-62703-068-7

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