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Introduction to Pharmacokinetics in Clinical Toxicology

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Computational Toxicology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 929))

Abstract

In clinical toxicology, a better understanding of the pharmacokinetics of the drugs may be useful in both risk assessment and formulating treatment guidelines for patients. Pharmacokinetics describes the time course of drug concentrations and is a driver for the time course of drug effects. In this chapter pharmacokinetics is described from a mathematical modeling perspective as applied to clinical toxicology. The pharmacokinetics of drugs are described using a combination of input and disposition (distribution and elimination) phases. A description of the time course of the input and disposition of drugs in overdose provides a basis for understanding the time course of effects of drugs in overdose. Relevant clinical toxicology examples are provided to explain various pharmacokinetic principles. Throughout this chapter we have taken a pragmatic approach to understanding and interpreting the time course of drug effects.

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Author information

Authors and Affiliations

  1. School of Pharmacy, University of Otago, Otago, New Zealand

    Pavan Vajjah & Stephen B. Duffull

  2. Systems Pharmacology Group, Simcyp Ltd, Sheffield, UK

    Pavan Vajjah

  3. Department of Clinical Toxicology and Pharmacology Calvary Mater Newcastle, University of Newcastle, Newcastle, NSW, Australia

    Geoffrey K. Isbister

  4. Discipline of Clinical Pharmacology, University of Newcastle, Newcastle, NSW, Australia

    Geoffrey K. Isbister

Authors
  1. Pavan Vajjah
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  2. Geoffrey K. Isbister
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  3. Stephen B. Duffull
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Corresponding author

Correspondence to Pavan Vajjah .

Editor information

Editors and Affiliations

  1. School of Biomedical Engineering, Chemical & Biological Engineering, Colorado State University, Campus Delivery 1370, Fort Collins, 80523-1370, Colorado, USA

    Brad Reisfeld

  2. , Chemical & Biological Engineering, Colorado State University, Campus Delivery 1370, Fort Collins, 80523-1370, Colorado, USA

    Arthur N. Mayeno

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Vajjah, P., Isbister, G.K., Duffull, S.B. (2012). Introduction to Pharmacokinetics in Clinical Toxicology. In: Reisfeld, B., Mayeno, A. (eds) Computational Toxicology. Methods in Molecular Biology, vol 929. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-050-2_12

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  • DOI: https://doi.org/10.1007/978-1-62703-050-2_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-049-6

  • Online ISBN: 978-1-62703-050-2

  • eBook Packages: Springer Protocols

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