Enhancement of Sperm Motility Using Pentoxifylline and Platelet-Activating Factor

  • Shilo L. Archer
  • William E. RoudebushEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 927)


Enhancement of sperm motility can effectively improve assisted reproductive technique outcomes. Here we describe two (pentoxifylline and platelet-activating factor) popular sperm motility enhancers and their respective methods.

Key words

Sperm Motility Pentoxifylline Platelet-activating factor PAF 


  1. 1.
    Ward A, Clissold SP (1987) Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 34:50–97PubMedCrossRefGoogle Scholar
  2. 2.
    Sikka SC, Hellstrom WJ (1991) The application of pentoxifylline in the stimulation of sperm motion in men undergoing electroejaculation. J Androl 12:165–170PubMedGoogle Scholar
  3. 3.
    Tesarik J et al (1992) Effect of pentoxifylline on sperm movement characteristics in normozoospermic and asthenozoospermic specimens. Hum Reprod 7:1257–1263PubMedGoogle Scholar
  4. 4.
    Lewis SE et al (1993) Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis. Fertil Steril 59:418–423PubMedGoogle Scholar
  5. 5.
    Pang SC et al (1993) Effects of pentoxifylline on sperm motility and hyperactivation in normozoospermic and normokinetic semen. Fertil Steril 60:336–343PubMedGoogle Scholar
  6. 6.
    Centola G et al (1995) Differential responses of human sperm to varying concentrations of pentoxyfylinne with demonstration of toxicity. J Androl 16:136–142PubMedGoogle Scholar
  7. 7.
    Patrizio P et al (2000) Effect of pentoxifylline on the intrinsic swimming forces of human sperm assessed by optical tweezers. J Androl 21:753–756PubMedGoogle Scholar
  8. 8.
    Roundebush W (2007) Seminal platelet-activating factor. Semin Thromb Hemost 33:69–74CrossRefGoogle Scholar
  9. 9.
    Roundebush W, Purnell E (2000) Platelet-activating factor content in human spermatozoa: predicting pregnancy outcome. Fertil Steril 74:257–260CrossRefGoogle Scholar
  10. 10.
    Harper MJ (1989) Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction? Biol Reprod 40:907–913PubMedCrossRefGoogle Scholar
  11. 11.
    Roudebush WE et al (2004) Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. Fertil Steril 82:52–56PubMedCrossRefGoogle Scholar
  12. 12.
    Levine AS et al (2002) A review of the effect of platelet-activating factor on male reproduction and sperm function. J Androl 23:471–476PubMedGoogle Scholar
  13. 13.
    Henkel RR, Schill WB (2003) Sperm preparation for ART. Reprod Biol Endocrinol 1:108PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department of BiologyCharleston Southern UniversityCharlestonUSA

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