Abstract
Encapsulation of gold nanoparticles within a silica shell is highly beneficial to the preparation of highly concentrated gold nanoparticles that can strongly absorb X-ray and hence be used as an X-ray contrast agent. This chapter describes a method for preparing highly concentrated colloidal gold nanoparticles suitable for an X-ray contrast agent application. It describes specific details of procedures for preparing spherical gold nanoparticles, forming thin silica shell on each gold nanoparticle, and enriching the silica-encapsulated gold nanoparticles.
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Acknowledgments
This chapter is based on author’s research work as a postdoctoral researcher and a visiting associate professor at Center for Interdisciplinary Research, Tohoku University, Sendai, Japan. I deeply thank to Professor Atsuo Kasuya and Professor Luis M. Liz-Marzán (Professor at University of Vigo, Spain) for their kind advice and help during my work.
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Park, YS. (2012). Preparation of Concentrated Colloids of Gold Core-Silica Shell Nanoparticles for Biomedical Applications. In: Soloviev, M. (eds) Nanoparticles in Biology and Medicine. Methods in Molecular Biology, vol 906. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-953-2_2
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DOI: https://doi.org/10.1007/978-1-61779-953-2_2
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