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Hematopoietic Stem Cell Mobilization with Agents Other than G-CSF

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Stem Cell Mobilization

Part of the book series: Methods in Molecular Biology ((MIMB,volume 904))

Abstract

Hematopoietic stem and progenitor mobilization has revolutionized the field of hematopoietic transplantation. Currently, hematopoietic grafts acquired from the peripheral blood of patients or donors treated with granulocyte-colony stimulating factor (G-CSF) are the preferred source for transplantation. G-CSF mobilization regimens, however, are associated with known morbidities and a significant number of normal donors and patient populations fail to mobilize sufficient numbers of hematopoietic stem and progenitor cells for transplantation, necessitating the need for non-G-CSF mobilization strategies. Mechanistic studies evaluating hematopoietic bone marrow niche interactions have uncovered novel agents with the capacity for hematopoietic mobilization. This chapter provides a comprehensive overview of mobilizing agents, other than G-CSF, and experimental procedures and technical aspects important to evaluate and define their hematopoietic mobilizing activities alone and in combination.

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Acknowledgments

Supported by NIH grants HL069669 and HL096305 (to LMP). JH is supported by training grant HL007910.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA

    Jonathan Hoggatt & Louis M. Pelus

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  1. Jonathan Hoggatt
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  2. Louis M. Pelus
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Correspondence to Louis M. Pelus .

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  1. Science Center at Houston, Inst. Molecular Medicine, University of Texas, Pressler Street 1825, Houston, 77030, Texas, USA

    Mikhail G. Kolonin

  2. Health Science Center, Houston, Inst. Molecular Medicine, University of Texas, Pressler Street 1825, Houston, 77030, Texas, USA

    Paul J. Simmons

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Hoggatt, J., Pelus, L.M. (2012). Hematopoietic Stem Cell Mobilization with Agents Other than G-CSF. In: Kolonin, M., Simmons, P. (eds) Stem Cell Mobilization. Methods in Molecular Biology, vol 904. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-943-3_4

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  • DOI: https://doi.org/10.1007/978-1-61779-943-3_4

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