Abstract
Antipsychotic drugs are becoming a larger part of the prescription drug market. In combination with traditional indications for prescribing these drugs, new effective therapies are proving worthwhile as well. Here, a successful method for detecting both first- and second-generation antipsychotics is presented using a solid phase extraction method and LC-MS/MS detection. This method is used for many sample matrices and can also be used for detecting antidepressants, which are often prescribed in conjunction with antipsychotics.
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References
Woods, L (2010) Antipsychotics—the top-selling prescription drug in the US. Articlesbase. http://www.articlesbase.com/diseases-and-conditions-articles/antipsychotics-the-top-selling-prescription-drug-in-the-us-2706505.html. Accessed 25 June 2010
McDonagh MS, Peterson K, Carson S, et al (2008) Drug class review: atypical antipsychotic drugs. Final report update 2. National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=antipsych. Accessed 25 June 2010
Shekelle P, Maglione M, Bagley S, Suttorp M, Mojica WA, Carter J, Rolon C, Hilton L, Zhou A, Chen S, Glassman P (2007) Executive summary: comparative effectiveness of off-label use of atypical antipsychotics. comparative effectiveness review no. 6. (Prepared by the Southern California/RAND evidence-based Practice Center under Contract No. 290-02-003.) Rockville, MD: Agency for healthcare research and quality. http://effectivehealthcare.ahrq.gov/index.cfm/search-for-guides-reviews-and-reports/?pageaction=displayproduct&productid=64. Accessed 25 June 2010
Baselt RC (2008) Disposition of toxic drugs and chemicals in man. Biomedical Publications, Foster City, CA
Shinozuka T, Terada M, Tanaka E (2006) Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method. Forensic Sci Int 162:108–112
Li KY, Cheng ZN, Li X et al (2004) Simultaneous determination of quetiapine and three metabolites in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry. Acta Pharmacol Sin 25:110–114
Priming the Degasser (2008) Agilent 1200 series micro vacuum degasser. Agilent Technologies, Inc.
Meatherall R, Younes J (2002) Fatality from olanzapine induced hyperglycemia. J Forensic Sci 47:893–896
HPLC Column Protection (2005) Phenomenex® chromatography columns and supplies
Agilent 6400 Series Triple Quad LC/MS System Quick Start Guide (2009) Agilent Technologies, Inc.
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© 2012 Springer Science+Business Media, LLC
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Kiely, E.R., Antonides, H.M. (2012). Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS. In: Langman, L., Snozek, C. (eds) LC-MS in Drug Analysis. Methods in Molecular Biology, vol 902. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-934-1_17
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DOI: https://doi.org/10.1007/978-1-61779-934-1_17
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-933-4
Online ISBN: 978-1-61779-934-1
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