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LC-MS in Drug Analysis pp 149–156Cite as

Hypoglycemic Agent Screening by LC-MS/MS

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 902))

Abstract

Hypoglycemia is a potentially life-threatening condition that can be caused by a variety of physiological conditions and pharmaceutical agents. Diagnosis of certain conditions, such as insulin-secreting tumors, requires ruling out the use (inadvertent or surreptitious) of drugs capable of inducing hypoglycemia. Many of the therapeutic agents used to treat diabetes mellitus have the ability to lower blood glucose to dangerous concentrations; these include the sulfonylurea, meglitinide, and thiazolidinedione drug classes. The LC-MS/MS assay presented herein provides qualitative or quantitative assessment of the most common of these drugs, for assistance in the differential diagnosis of hypoglycemia.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, & Pathology, Mayo Clinic, Rochester, MN, USA

    Eric W. Korman

  2. Department of Laboratory Medicine, Mayo Clinic, Rochester, MN, USA

    Loralie J. Langman & Christine L. H. Snozek

Authors
  1. Eric W. Korman
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  2. Loralie J. Langman
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  3. Christine L. H. Snozek
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Corresponding author

Correspondence to Loralie J. Langman .

Editor information

Editors and Affiliations

  1. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Loralie J. Langman

  2. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Christine L. H. Snozek

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© 2012 Springer Science+Business Media, LLC

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Korman, E.W., Langman, L.J., Snozek, C.L.H. (2012). Hypoglycemic Agent Screening by LC-MS/MS. In: Langman, L., Snozek, C. (eds) LC-MS in Drug Analysis. Methods in Molecular Biology, vol 902. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-934-1_13

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  • DOI: https://doi.org/10.1007/978-1-61779-934-1_13

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-933-4

  • Online ISBN: 978-1-61779-934-1

  • eBook Packages: Springer Protocols

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