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LC-MS/MS Screen for Xenobiotics and Metabolites

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Book cover LC-MS in Drug Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 902))

Abstract

Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is now considered as a perfect complement to HPLC-DAD (diode array detection) and gas chromatography (GC)-MS for the general unknown screening of drugs and toxic compounds.

Here we describe a procedure applied routinely in our laboratory for clinical and forensic applications using the QTRAP™ technology.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology-Toxicology-Pharmacovigilance, Centre Hospitalier Universitaire (CHU) de Limoges, Limoges, France

    François-Ludovic Sauvage & Pierre Marquet

Authors
  1. François-Ludovic Sauvage
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  2. Pierre Marquet
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Corresponding author

Correspondence to Pierre Marquet .

Editor information

Editors and Affiliations

  1. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Loralie J. Langman

  2. Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Christine L. H. Snozek

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© 2012 Springer Science+Business Media, LLC

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Sauvage, FL., Marquet, P. (2012). LC-MS/MS Screen for Xenobiotics and Metabolites. In: Langman, L., Snozek, C. (eds) LC-MS in Drug Analysis. Methods in Molecular Biology, vol 902. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-934-1_11

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  • DOI: https://doi.org/10.1007/978-1-61779-934-1_11

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-933-4

  • Online ISBN: 978-1-61779-934-1

  • eBook Packages: Springer Protocols

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