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Electrophysiological-Metabolic Modeling of Microbes: Applications in Fuel Cells and Environment Analysis

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Microbial Systems Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 881))

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Abstract

A formalism for simulating coupled metabolic and electrophysiological processes is presented. The resulting chemical kinetic and electrophysiological equations are solved numerically to create a cell simulator. Metabolic features of this simulator were adapted from Karyote, a multi-compartment biochemical cell modeling simulator. We present the mathematical formalism and its computational implementation as an integrated electrophysiological-metabolic model. Applications to Geobacter sulfurreducens in the environment and in a fuel cell are discussed.

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Acknowledgments

This work was funded in part by the Undergraduate Medical Academy at Prairie View A&M University, and the Indiana University College of Arts and Sciences through the Center for Cell and Virus Theory.

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Authors and Affiliations

  1. Department of Chemistry, Prairie View A&M University, Prairie View, TX, USA

    Max Fontus

  2. Department of Chemistry, Center for Cell and Virus Theory, Indiana University, Bloomington, IN, USA

    Peter Ortoleva

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  1. Max Fontus
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  2. Peter Ortoleva
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Correspondence to Peter Ortoleva .

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Editors and Affiliations

  1. Physics & Life Sciences Directorate, Biosciences & Biotechnology Div., Lawrence Livermore National Laboratory, East Avenue 7000, Livermore, 94551, California, USA

    Ali Navid

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Fontus, M., Ortoleva, P. (2012). Electrophysiological-Metabolic Modeling of Microbes: Applications in Fuel Cells and Environment Analysis. In: Navid, A. (eds) Microbial Systems Biology. Methods in Molecular Biology, vol 881. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-827-6_14

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  • DOI: https://doi.org/10.1007/978-1-61779-827-6_14

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-826-9

  • Online ISBN: 978-1-61779-827-6

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