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Protein Kinase Technologies pp 349–360Cite as

Electrophysiological Technique for Analysis of Synaptic Function of PKN1 in Hippocampus

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Part of the book series: Neuromethods ((NM,volume 68))

Abstract

PKNs are serine/threonine protein kinases that have conserved catalytic domains homologous to those of protein kinase C (PKC) family members and regulatory regions containing antiparallel coiled-coil (ACC) domains and C2-like domains. PKN1 in particular is abundant in the brain, and the physiological role of this enzyme has been examined by generating PKN1 genetically modified mice and inhibitors of this enzyme. Here, we review electrophysiological techniques to analyze synaptic functions in the CA1 region of the hippocampus using these mice and inhibitors.

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Author information

Authors and Affiliations

  1. Education and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Japan

    Hiroki Yasuda

  2. Biosignal Research Center, Kobe University, Kobe, Japan

    Hideyuki Mukai

Authors
  1. Hiroki Yasuda
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  2. Hideyuki Mukai
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Corresponding author

Correspondence to Hiroki Yasuda .

Editor information

Editors and Affiliations

  1. Biosignal Research Center, Kobe University, Rokkodai 1-1, Kobe, 657-8501, Japan

    Hideyuki Mukai

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Yasuda, H., Mukai, H. (2012). Electrophysiological Technique for Analysis of Synaptic Function of PKN1 in Hippocampus. In: Mukai, H. (eds) Protein Kinase Technologies. Neuromethods, vol 68. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-824-5_19

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  • DOI: https://doi.org/10.1007/978-1-61779-824-5_19

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-823-8

  • Online ISBN: 978-1-61779-824-5

  • eBook Packages: Springer Protocols

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