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Structural and Vascular Analysis of Tissue Engineering Scaffolds, Part 1: Numerical Fluid Analysis

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Book cover Computer-Aided Tissue Engineering

Part of the book series: Methods in Molecular Biology ((MIMB,volume 868))

Abstract

Rapid prototyping technologies were recently introduced in the medical field, being particularly viable to produce porous scaffolds for tissue engineering. These scaffolds should be biocompatible, biodegradable, with appropriate porosity, pore structure, and pore distribution on top of presenting both surface and structural compatibility. This chapter presents the state-of-the-art in tissue engineering and scaffold design using numerical fluid analysis for optimal vascular design. The vascularization of scaffolds is an important aspect due to its influence regarding the normal flow of biofluids within the human body. This computational tool also allows to design either a scaffold offering less resistance to the normal flow of biofluids or reducing the possibility for blood coagulation through forcing the flow toward a specific direction.

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Acknowledgements

This research is supported by the Portuguese Foundation of Science and Technology through a PhD grant of Henrique Almeida (SFRH/BD/37604/2007). The authors also wish to thank the sponsorship given by CYTED through a Biomanufacturing Network “Rede Iberoamericana de Biofabricação”.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Institute for Polymers and Composites, School of Technology and Management, Polytechnic Institute of Leiria, Leiria, Portugal

    Henrique A. Almeida

  2. Centre for Rapid and Sustainable Product Development, Department of Mechanical Engineering, Institute for Polymers and Composites, School of Technology and Management, Polytechnic Institute of Leiria, Leiria, Portugal

    Paulo J. Bártolo

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  1. Henrique A. Almeida
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  2. Paulo J. Bártolo
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Correspondence to Paulo J. Bártolo .

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Editors and Affiliations

  1. , Department of Neurosurgery, Baylor College of Medicine, Holcombe Blvd. 2002, Houston, 77030, Texas, USA

    Michael A.K. Liebschner

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Almeida, H.A., Bártolo, P.J. (2012). Structural and Vascular Analysis of Tissue Engineering Scaffolds, Part 1: Numerical Fluid Analysis. In: Liebschner, M. (eds) Computer-Aided Tissue Engineering. Methods in Molecular Biology, vol 868. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-764-4_12

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  • DOI: https://doi.org/10.1007/978-1-61779-764-4_12

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