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Animal Models

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Influenza Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 865))

Abstract

Five well-established animal models in influenza research are discussed in a schematic fashion. Although there are clear parallels between these models, like viruses used, housing and handling conditions under biosafety conditions, routes of virus inoculation, sampling strategies, and necropsy techniques (mostly elaborated on in Subheading 4), each of these models involves specific differences in their practical applicability that need thorough assessment depending on the scientific question raised. In other words, there is no universal animal model for influenza and depending on the actual question to be answered the model and the experimental conditions should be carefully selected.

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Authors and Affiliations

  1. Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands

    Edwin J. B. Veldhuis Kroeze, Thijs Kuiken & Albert D. M. E. Osterhaus

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  1. Edwin J. B. Veldhuis Kroeze
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  2. Thijs Kuiken
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  3. Albert D. M. E. Osterhaus
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Correspondence to Albert D. M. E. Osterhaus .

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Editors and Affiliations

  1. School of Veterinary Medicine, Dept. Pathobiological Science, University of Wisconsin-Madison, Science Drive 575, Madison, 53711, Wisconsin, USA

    Yoshihiro Kawaoka

  2. Influenza Research Institute (IRI), Dept. Pathobiological Science, University of Wisconsin-Madison, Science Drive 575, Madison, 53711, Wisconsin, USA

    Gabriele Neumann

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Kroeze, E.J.B.V., Kuiken, T., Osterhaus, A.D.M.E. (2012). Animal Models. In: Kawaoka, Y., Neumann, G. (eds) Influenza Virus. Methods in Molecular Biology, vol 865. Humana Press. https://doi.org/10.1007/978-1-61779-621-0_8

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  • DOI: https://doi.org/10.1007/978-1-61779-621-0_8

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