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Cancer Epigenetics pp 155–176Cite as

DNA Methylation Changes in Cervical Cancers

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 863))

Abstract

Cervical carcinoma is one of the major causes of death in women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radiation; therefore, testing of molecular targeted therapies against this malignancy is highly desirable. Cervical cancer is a multistep process with accumulation of genetic and epigenetic alterations in regulatory genes, leading to activation of oncogenes and inactivation or loss of tumor suppressor genes (TSGs). In the last decade, in addition to genetic alterations, epigenetic inactivation of TSGs by promoter hypermethylation has been recognized as an important and alternative mechanism in tumorigenesis. In cervical cancer, epigenetic alterations can affect the expression of papillomavirus as well as host genes in relation to stages representing the multistep process of carcinogenesis. Here we discuss these epigenetic alterations in cervical cancer focusing on DNA methylation.

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  1. Department of Obstetrics and Gynecology, Affiliated Hospital of Qingdao University School of Medicine, Qingdao, China

    Qiang Lu, Dehua Ma & Shuping Zhao

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  1. Qiang Lu
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    Ramona G. Dumitrescu

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    Mukesh Verma

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Lu, Q., Ma, D., Zhao, S. (2012). DNA Methylation Changes in Cervical Cancers. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 863. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-612-8_9

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  • DOI: https://doi.org/10.1007/978-1-61779-612-8_9

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-611-1

  • Online ISBN: 978-1-61779-612-8

  • eBook Packages: Springer Protocols

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