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Epigenetics of Solid Cancer Stem Cells

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Cancer Epigenetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 863))

Abstract

Epigenetics is an emerging science that can help to explain carcinogenesis. The possibility that carcinogenesis may originate in a stem cell process was proposed recently. Stem cells are generated and contribute to tumor formation during the process of tumor development. This chapter focuses on the role of epigenetics and genetics in stem cell formation, different theories about the origin of cancer stem cells (CSCs), and epigenetic mechanisms that occur in solid CSCs. Potential applications of knowledge gained through this field and future prospects for cancer treatment also are discussed.

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Abbreviations

ChIP:

Chromatin immunoprecipitation

CSCs:

Cancer stem cells

DREAM:

Digital restriction enzyme analysis of methylation

HATs:

Histone acetyltransferases

HDACs:

Histone deacetylases

HDMs:

Histone demethylases

HMTs:

Histone methyltransferases

iPSC:

Induced pluripotent stem cell

LOI:

Loss of imprinting

PcG:

Polycomb group genes

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Authors and Affiliations

  1. Ambedkar Center for Biomedical Research (ACBR), Delhi University, Delhi, India

    Alok Mishra

  2. Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Alok Mishra

  3. Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, USA

    Mukesh Verma

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  1. Alok Mishra
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  2. Mukesh Verma
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Correspondence to Mukesh Verma .

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Editors and Affiliations

  1. School of Medicine, Saba University, Saba, Dutch Antilles

    Ramona G. Dumitrescu

  2. National Institutes of Health (NIH), Div. Cancer Control &, National Cancer Institute, Executive Blvd. 6130Suite 5100, Bethesda, 20892-7324, Maryland, USA

    Mukesh Verma

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Mishra, A., Verma, M. (2012). Epigenetics of Solid Cancer Stem Cells. In: Dumitrescu, R., Verma, M. (eds) Cancer Epigenetics. Methods in Molecular Biology, vol 863. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-612-8_2

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  • DOI: https://doi.org/10.1007/978-1-61779-612-8_2

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