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Assessing Epilepsy-Related Behavioral Phenotypes in Adult Zebrafish

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Zebrafish Protocols for Neurobehavioral Research

Part of the book series: Neuromethods ((NM,volume 66))

Abstract

Over the past decades, zebrafish have been presented as a novel and valuable tool for modeling complex human diseases. Epilepsy is a serious brain disorder with multiple genetic and environmental causes. Our poor understanding of its pathogenesis requires novel paradigms and model organism for translational experimental epilepsy research. Seizure-like behavior has already been studied in both larval and adult zebrafish models, including genetically modified strains and convulsant drugs. This protocol describes how to quantify seizure-like behavioral phenotypes commonly observed in adult zebrafish models of epilepsy.

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Acknowledgments

The study was supported by Tulane University Intramural funds, Zebrafish Neuroscience Research Consortium (ZNRC), LA Board of Regents P-Fund and Tulane University Synergy grant to AVK.

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Authors and Affiliations

  1. Department of Pharmacology and Neuroscience Program, Tulane University Medical School, New Orleans, LA, USA

    Daniel Desmond, Evan Kyzar, Siddharth Gaikwad, Jeremy Green, Russell Riehl & Andrew Roth

  2. Department of Pharmacology, Tulane University, New Orleans, LA, USA

    Adam Michael Stewart

  3. Neuroscience Program, Department of Pharmacology, Tulane University, New Orleans, LA, USA

    Allan V. Kalueff

Authors
  1. Daniel Desmond
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  2. Evan Kyzar
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  3. Siddharth Gaikwad
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  4. Jeremy Green
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  5. Russell Riehl
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  6. Andrew Roth
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  7. Adam Michael Stewart
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  8. Allan V. Kalueff
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Corresponding author

Correspondence to Allan V. Kalueff .

Editor information

Editors and Affiliations

  1. Neuroscience Program, Department of Pharmacology, Tulane University, Tulane Ave. 1430, New Orleans, 70112, Louisiana, USA

    Allan V. Kalueff

  2. , Department of Pharmacology, Tulane University, Tulane Avenue 1430, New Orleans, 70112, Louisiana, USA

    Adam Michael Stewart

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© 2012 Springer Science+Business Media, LLC

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Desmond, D. et al. (2012). Assessing Epilepsy-Related Behavioral Phenotypes in Adult Zebrafish. In: Kalueff, A., Stewart, A. (eds) Zebrafish Protocols for Neurobehavioral Research. Neuromethods, vol 66. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-597-8_24

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  • DOI: https://doi.org/10.1007/978-1-61779-597-8_24

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-596-1

  • Online ISBN: 978-1-61779-597-8

  • eBook Packages: Springer Protocols

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