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Forelimb Use Asymmetry Analysis of Vertical Exploratory Activity After Intracerebral Hemorrhage in Rats and Mice

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Animal Models of Acute Neurological Injuries II

Part of the book series: Springer Protocols Handbooks ((SPH))

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Abstract

Intracerebral hemorrhage (ICH) leads to lasting sensorimotor deficits in humans. The test of forelimb use asymmetry (FUA) has been repeatedly shown to be effective for the longitudinal evaluation of sensorimotor function in rat and mouse models of ICH. This test evaluates the use of forelimbs during weight shifting for vertical exploration in a cylindrical enclosure, and can monitor the recovery of sensorimotor function without the effect of learning after repeated testing. Relevant descriptions for performing these assessments are presented in this chapter.

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Author information

Authors and Affiliations

  1. Department of Physiology and Pharmacology, Loma Linda University Medical Center, Loma Linda, CA, USA

    Tim Lekic, Anatol Manaenko & William Rolland

  2. Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

Authors
  1. Tim Lekic
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  2. Anatol Manaenko
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  3. William Rolland
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  4. John H. Zhang
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Corresponding author

Correspondence to John H. Zhang .

Editor information

Editors and Affiliations

  1. School of Medicine, University of Pittsburgh, Terrace St. 3500, Pittsburgh, 15213, Pennsylvania, USA

    Jun Chen

  2. School of Medicine, Stark Neurosciences Res. Inst., Indiana University, W. Walnut St. 950, Indianapolis, 46202, Indiana, USA

    Xiao-Ming Xu

  3. School of Medicine, Department of Anatomy & Cell Biology, Indiana University, Barnhill Dr. 635, Indianapolis, 46202, Indiana, USA

    Zao C. Xu

  4. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    John H. Zhang

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Lekic, T., Manaenko, A., Rolland, W., Zhang, J.H. (2012). Forelimb Use Asymmetry Analysis of Vertical Exploratory Activity After Intracerebral Hemorrhage in Rats and Mice. In: Chen, J., Xu, XM., Xu, Z., Zhang, J. (eds) Animal Models of Acute Neurological Injuries II. Springer Protocols Handbooks. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-576-3_54

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  • DOI: https://doi.org/10.1007/978-1-61779-576-3_54

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-575-6

  • Online ISBN: 978-1-61779-576-3

  • eBook Packages: Springer Protocols

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