Abstract
The primary cause of poor outcome after subarachnoid hemorrhage (SAH) consists of many factors including cerebral vasospasm and early brain injury. Animal studies usually focus on one factor among them, and the difference in endpoints may cause lack of translation of treatments effective in animals to humans. Thus, functional outcome has become a key parameter to determine the efficacy of therapeutic interventions. The neurological scoring system reported by Garcia et al. with or without a modification has been most widely used to investigate early pathophysiological changes after SAH. The scale consists of six tests (spontaneous activity, spontaneous movement of all four limbs, forepaw outstretching, climbing, body proprioception, and response to whisker stimulation) and is scored 2–18. This chapter introduces a brief history, methods, and variations of the modified Garcia’s scale.
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Suzuki, H., Zhang, J.H. (2012). Neurobehavioral Assessments of Subarachnoid Hemorrhage. In: Chen, J., Xu, XM., Xu, Z., Zhang, J. (eds) Animal Models of Acute Neurological Injuries II. Springer Protocols Handbooks. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-576-3_31
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DOI: https://doi.org/10.1007/978-1-61779-576-3_31
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