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Assessment of Cell Death: Apoptosis, Necrosis, or In Between

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Animal Models of Acute Neurological Injuries II

Part of the book series: Springer Protocols Handbooks ((SPH))

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Abstract

Cell death and cell survival are the fundamental events in development and pathological conditions associated with virtually all disorders in the central nervous system (CNS) and peripheral nervous system (PNS). Assessment of cell death and identification of the type of cell death are critical for understanding the mechanism of the injury and for development of therapeutic treatment of diseases. Recent development in cellular and molecular biological discoveries has allowed better characterization of different cell death including necrosis, apoptosis, and autophagic death and development of numerous cell death assays. This chapter intends to introduce some common characteristics of different types of cell death and the most basic principle of assessments. Emerging evidence also show that sometimes it is difficult to separate different cell death mechanisms, and mixed cell death often is observed under in vivo situation. We hope the content of this chapter will help readers to better understand and develop novel ideas of cell death in diseases.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA

    Thomas Genetta

  2. Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA

    Thomas Genetta

  3. Departments of Anesthesiology and Neurology, Emory University School of Medicine, Atlanta, GA, USA

    Ling Wei & Shan Ping Yu

Authors
  1. Thomas Genetta
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  2. Ling Wei
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  3. Shan Ping Yu
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Corresponding author

Correspondence to Shan Ping Yu .

Editor information

Editors and Affiliations

  1. School of Medicine, University of Pittsburgh, Terrace St. 3500, Pittsburgh, 15213, Pennsylvania, USA

    Jun Chen

  2. School of Medicine, Stark Neurosciences Res. Inst., Indiana University, W. Walnut St. 950, Indianapolis, 46202, Indiana, USA

    Xiao-Ming Xu

  3. School of Medicine, Department of Anatomy & Cell Biology, Indiana University, Barnhill Dr. 635, Indianapolis, 46202, Indiana, USA

    Zao C. Xu

  4. School of Medicine, Dept. Neurosurgery, Loma Linda University, Anderson St. 11234, Loma Linda, 92354, California, USA

    John H. Zhang

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Genetta, T., Wei, L., Yu, S.P. (2012). Assessment of Cell Death: Apoptosis, Necrosis, or In Between. In: Chen, J., Xu, XM., Xu, Z., Zhang, J. (eds) Animal Models of Acute Neurological Injuries II. Springer Protocols Handbooks. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-576-3_2

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  • DOI: https://doi.org/10.1007/978-1-61779-576-3_2

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-575-6

  • Online ISBN: 978-1-61779-576-3

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