Abstract
In this chapter, we describe the usage of this rheumatoid arthritis model to investigate pain-like behavior in mice, including the assessment of clinical changes and the time-dependent changes in nociceptive behavior during disease progresses.
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References
Sokka, T., Kautiainen, H., Toloza, S., Makinen, H., Verstappen, S. M., Lund Hetland, M., Naranjo, A., Baecklund, E., Herborn, G., Rau, R., Cazzato, M., Gossec, L., Skakic, V., Gogus, F., Sierakowski, S., Bresnihan, B., Taylor, P., McClinton, C., and Pincus, T. (2007) QUEST-RA: quantitative clinical assessment of patients with rheumatoid arthritis seen in standard rheumatology care in 15 countries, Ann Rheum Dis 66, 1491–1496.
Taylor, P. C. (2010) The importance of the patients’ experience of RA compared with clinical measures of disease activity, Clin Exp Rheumatol 28, S28–31.
Christianson, C. A., Corr, M., Firestein, G. S., Mobargha, A., Yaksh, T. L., and Svensson, C. I. (2010) Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis, Pain 151, 394–403.
Kouskoff, V., Korganow, A. S., Duchatelle, V., Degott, C., Benoist, C., and Mathis, D. (1996) Organ-specific disease provoked by systemic autoimmunity, Cell 87, 811–822.
Matsumoto, I., Staub, A., Benoist, C., and Mathis, D. (1999) Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme, Science 286, 1732–1735.
Ji, H., Gauguier, D., Ohmura, K., Gonzalez, A., Duchatelle, V., Danoy, P., Garchon, H. J., Degott, C., Lathrop, M., Benoist, C., and Mathis, D. (2001) Genetic influences on the end-stage effector phase of arthritis, J Exp Med 194, 321–330.
Monach, P., Hattori, K., Huang, H., Hyatt, E., Morse, J., Nguyen, L., Ortiz-Lopez, A., Wu, H. J., Mathis, D., and Benoist, C. (2007) The K/BxN mouse model of inflammatory arthritis: theory and practice, Methods Mol Med 136, 269–282.
Monach, P. A., Mathis, D., and Benoist, C. (2008) The K/BxN arthritis model, Curr Protoc Immunol Chapter 15, Unit 15 22.
Dixon, W. J. (1980) Efficient analysis of experimental observations, Annu Rev Pharmacol Toxicol 20, 441–462.
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., and Yaksh, T. L. (1994) Quantitative assessment of tactile allodynia in the rat paw, J Neurosci Methods 53, 55–63.
Mogil, J. S., Wilson, S. G., Bon, K., Lee, S. E., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., Elmer, G. I., Chung, J. M., and Devor, M. (1999) Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception, Pain 80, 67–82.
Dirig, D. M., Salami, A., Rathbun, M. L., Ozaki, G. T., and Yaksh, T. L. (1997) Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli, J Neurosci Methods 76, 183–191.
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Christianson, C.A., Corr, M., Yaksh, T.L., Svensson, C.I. (2012). K/BxN Serum Transfer Arthritis as a Model of Inflammatory Joint Pain. In: Luo, Z. (eds) Pain Research. Methods in Molecular Biology, vol 851. Humana Press. https://doi.org/10.1007/978-1-61779-561-9_19
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DOI: https://doi.org/10.1007/978-1-61779-561-9_19
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