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Host-Fungus Interactions pp 519–525Cite as

Invasive Models of Histoplasmosis

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 845))

Abstract

Histoplasmosis results from infection with the fungal organism Histoplasma capsulatum. Most Histoplasma research today uses models based on primary pulmonary infection. Following inhalation, conidia are rapidly ingested and intracellularly convert to the yeast form. After initial pulmonary infection, organisms are carried throughout the body giving rise to disseminated infection. Three murine infection models have been developed which mimic human disease. These comprise models of primary infection following initial exposure to the organism, secondary exposure to Histoplasma following spontaneous recovery from primary disease and a model of reactivated infection following spontaneous clearance of primary disease. This chapter describes these models and explores variability introduced with the use of mice of varied genetic backgrounds and different H. capsulatum strains.

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Author information

Authors and Affiliations

  1. Infectious Disease Division, Cincinnati VA Medical Center, University of Cincinnati, Cincinnati, OH, USA

    A. George Smulian

Authors
  1. A. George Smulian
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Corresponding author

Correspondence to A. George Smulian .

Editor information

Editors and Affiliations

  1. Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom

    Alexandra C. Brand

  2. Institute of Medical Sciences, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, United Kingdom

    Donna M. MacCallum

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© 2012 Springer Science+Business Media, LLC

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Smulian, A.G. (2012). Invasive Models of Histoplasmosis. In: Brand, A., MacCallum, D. (eds) Host-Fungus Interactions. Methods in Molecular Biology, vol 845. Humana, Totowa, NJ. https://doi.org/10.1007/978-1-61779-539-8_37

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  • DOI: https://doi.org/10.1007/978-1-61779-539-8_37

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  • Publisher Name: Humana, Totowa, NJ

  • Print ISBN: 978-1-61779-538-1

  • Online ISBN: 978-1-61779-539-8

  • eBook Packages: Springer Protocols

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