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Clinical Uses of Liver Stem Cells

  • Yock Young DanEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 826)

Abstract

Liver transplantation offers a definitive cure for many liver and metabolic diseases. However, the complex invasive procedure and paucity of donor liver graft organs limit its clinical applicability. Liver stem cells provide a potentially limitless source of cells that would be useful for a variety of clinical applications. These stem cells or hepatocytes generated from them can be used in cellular transplantation, bioartificial liver devices and drug testing in the development of new drugs. In this chapter, we review the technical aspects of clinical applications of liver stem cells and the progress made to date in the clinical setting. The difficulties and challenges of realizing the potential of these cells are discussed.

Key words

Liver stem cells Liver progenitor cells Hepatocyte transplantation Bioartificial liver-assisted device 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Medicine, Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

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