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The KEGG Databases and Tools Facilitating Omics Analysis: Latest Developments Involving Human Diseases and Pharmaceuticals

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Next Generation Microarray Bioinformatics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 802))

Abstract

In this chapter, we demonstrate the usability of the KEGG (Kyoto encyclopedia of genes and genomes) databases and tools, especially focusing on the visualization of the omics data. The desktop application KegArray and many Web-based tools are tightly integrated with the KEGG knowledgebase, which helps visualize and interpret large amount of data derived from high-throughput measurement techniques including microarray, metagenome, and metabolome analyses. Recently developed resources for human disease, drug, and plant research are also mentioned.

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References

  1. Kanehisa M, Goto S, Furumichi M et al (2010) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38:D355-360.

    Article  PubMed  CAS  Google Scholar 

  2. KEGG Home Page. http://www.kegg.jp/.

  3. GenomeNet. http://www.genome.jp/.

  4. Fujibuchi W, Sato K, Ogata H et al (1998) KEGG and DBGET/LinkDB: Integration of biological relationships in divergent molecular biology data. In: Knowledge Sharing Across Biological and Medical Knowledge Based Systems. Technical Report WS-98-04, pp 35–40, AAAI Press.

    Google Scholar 

  5. Goto S, Okuno Y, Hattori M et al (2002) LIGAND: database of chemical compounds and reactions in biological pathways. Nucleic Acids Res 30:402–404.

    Article  PubMed  CAS  Google Scholar 

  6. KEGG PATHWAY. http://www.kegg.jp/kegg/pathway.html.

  7. KEGG Markup Language. http://www.genome.jp/kegg/xml/.

  8. Okuda S, Yamada T, Hamajima M et al (2008) KEGG Atlas mapping for global analysis of metabolic pathways. Nucleic Acids Res 36:W423-426.

    Article  PubMed  CAS  Google Scholar 

  9. KEGG BRITE. http://www.genome.jp/kegg/brite.html.

  10. PATHWAY color Page. http://www.genome.jp/kegg/tool/color_pathway.html.

  11. BRITE color Page. http://www.genome.jp/kegg/tool/color_brite.html.

  12. KEGG API. http://www.genome.jp/kegg/soap/.

  13. KegTools Page. http://www.genome.jp/kegg/download/kegtools.html.

  14. KEGG EXPRESSION database. http://www.genome.jp/kegg/expression/.

  15. KEGG DISEASE. http://www.genome.jp/kegg/disease/.

  16. KEGG DRUG. http://www.genome.jp/kegg/drug/.

  17. Shigemizu D, Araki M, Okuda S et al (2009) Extraction and analysis of chemical modification patterns in drug development. J Chem Inf Model 49:1122–1129.

    Article  PubMed  CAS  Google Scholar 

  18. EDRUG database. http://www.genome.jp/kegg/drug/edrug.html.

  19. Masoudi-Nejad A, Goto S, Jauregui R et al (2007) EGENES: transcriptome-based plant database of genes with metabolic pathway information and expressed sequence tag indices in KEGG. Plant Physiol 144:857–866.

    Article  PubMed  CAS  Google Scholar 

  20. Wheelock CE, Wheelock AM, Kawashima S et al (2009) Systems biology approaches and pathway tools for investigating cardiovascular disease. Mol Biosyst 5:588–602.

    Article  PubMed  CAS  Google Scholar 

  21. Wheelock CE, Goto S, Yetukuri L et al (2009) Bioinformatics strategies for the analysis of lipids. Methods Mol Biol 580:339–368.

    Article  PubMed  CAS  Google Scholar 

  22. KEGG GENES. http://www.genome.jp/kegg/genes.html.

  23. KEGG Organism Page. http://www.genome.jp/kegg/catalog/org_list.html.

  24. KEGG GENOME Page. http://www.genome.jp/kegg/genome.html.

  25. Moriya Y, Itoh M, Okuda S et al (2007) KAAS: an automatic genome annotation and pathway reconstruction server. Nucleic Acids Res 35:W182-185.

    Article  PubMed  Google Scholar 

  26. KAAS Page. http://www.genome.jp/tools/kaas/.

  27. DBGET Page. http://www.genome.jp/dbget/.

  28. KEGG Identifier Page. http://www.genome.jp/kegg/kegg3.html.

  29. Moriya Y, Shigemizu D, Hattori M et al (2010) PathPred: an enzyme-catalyzed metabolic pathway prediction server. Nucleic Acids Res 38:W138-143.

    Article  PubMed  CAS  Google Scholar 

  30. Kotera M, Okuno Y, Hattori M et al (2004) Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions. J Am Chem Soc 126:16487–16498.

    Article  PubMed  CAS  Google Scholar 

  31. Yamanishi Y, Hattori M, Kotera M et al (2009) E-zyme: predicting potential EC numbers from the chemical transformation pattern of substrate-product pairs. Bioinformatics 25:i179-186.

    Article  PubMed  CAS  Google Scholar 

  32. Hashimoto K, Kanehisa M (2008) KEGG GLYCAN for integrated analysis of pathways, genes, and structures. In: Taniguchi N, Suzuki A, Ito Y, Narimatsu H, Kawasaki T, Hase S (eds.) Experimental Glycoscience. pp 441–444, Springer.

    Google Scholar 

  33. Hattori M, Okuno Y, Goto S et al (2003) Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways. J Am Chem Soc 125: 11853–11865.

    Article  PubMed  CAS  Google Scholar 

  34. Hattori M, Tanaka N, Kanehisa M et al (2010) SIMCOMP/SUBCOMP: chemical structure search servers for network analyses. Nucleic Acids Res 38:W652-656.

    Article  PubMed  CAS  Google Scholar 

  35. Aoki KF, Yamaguchi A, Ueda N et al (2004) KCaM (KEGG Carbohydrate Matcher): a software tool for analyzing the structures of carbohydrate sugar chains. Nucleic Acids Res 32:W267-272.

    Article  PubMed  CAS  Google Scholar 

  36. KEGG FTP Site. http://www.genome.jp/kegg/download/.

  37. KEGG Feedback. http://www.genome.jp/feedback/.

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Acknowledgments

The computational resources were provided by the Bioinformatics Center, Institute for Chemical Research, Kyoto University. The KEGG project is supported by the Institute for Bioinformatics Research and Development of the Japan Science and Technology Agency, and a grant-in-aid for scientific research on the priority area “Comprehensive Genomics” from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Correspondence to Masaaki Kotera .

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Kotera, M., Hirakawa, M., Tokimatsu, T., Goto, S., Kanehisa, M. (2012). The KEGG Databases and Tools Facilitating Omics Analysis: Latest Developments Involving Human Diseases and Pharmaceuticals. In: Wang, J., Tan, A., Tian, T. (eds) Next Generation Microarray Bioinformatics. Methods in Molecular Biology, vol 802. Humana Press. https://doi.org/10.1007/978-1-61779-400-1_2

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  • DOI: https://doi.org/10.1007/978-1-61779-400-1_2

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-399-8

  • Online ISBN: 978-1-61779-400-1

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