Electrospinning Technology in Tissue Regeneration
Electrospinning is one of the most versatile and effective tools to produce nanostructured fibers in the biomedical science fields. The nanofibrous structure with diameters from tens to hundreds of nanometers largely mimics the native extracellular matrix (ECM) of many tissues. Thus far, a range of compositions including polymers and ceramics and their composites/hybrids have been successfully applied for generating electrospun nanofibers. Different processing tools in electrospinning set-ups and assemblies are currently developed to tune the morphology and properties of nanofibers. Herein, we demonstrate the electrospinning process and the electrospun biomaterials for specific use in tissue regeneration with some examples, involving different material combinations and fiber morphologies.
Key wordsElectrospinning Nanostructured fibers Nanofibers Polymer Composites Ceramic Tissue regeneration
This work was supported by the WCU program through the NRF funded by the MEST, Korea (R31-10069). Dr. O. Castaño thanks the Ramón y Cajal programme of the MICINN.
- 1.Cooley, J.F. (1902) Apparatus for electrically dispersing fluids US Patent Specification, 692631.Google Scholar
- 2.Morton, W.J. (1902), Method of dispersing fluids US Patent Specification, 705691.Google Scholar
- 3.Formhals, A. (1934), Process and apparatus for preparing artificial threads US Patent Specification, 1975504.Google Scholar
- 4.Gilbert, W. (1628), De Magnete, Magneticisque Corporibus, et de Magno Magnete Tellure, London, Peter Short.Google Scholar
- 5.Gray, S., and Mortimer C. (1732), A letter concerning the electricity of water, Phil. Trans, 37, 227–260.Google Scholar
- 6.Rayleigh, L. (1882), On the Equilibrium of Liquid Conducting Masses charged with Electricity, Philosophical Magazine, 14, 184–186Google Scholar
- 11.Nolan, J.J. (1926) Proc. R. Ir. Acad. Sect, A 37, 28–39.Google Scholar
- 12.Macky W. A. (1931) Some Investigations on the Deformation and Breaking of Water Drops in Strong Electric Fields, Proceedings of the Royal Society of London, Series A 133 (822), 565–587.Google Scholar
- 13.Taylor, G. (1964) Disintegration of Water Droplets in an Electric Field, Proc. Roy. Soc. London, Ser. A 280, 1382, 383–397.Google Scholar
- 17.Liao, S., Li, B., Ma, Z., Wei, H., Chan, C., and Ramakrishna, S. (2006) Biomimetic electrospun nanofibers for tissue regeneration, Biomed. Mater, 1 R45.Google Scholar
- 22.Gunatillake, P.A., and Adhikari, R. (2003) Biodegradable synthetic polymers for tissue engineering, Eur Cell Mater, 20, 5, 1–16.Google Scholar