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Stimuli Responsive Polymers for Nanoengineering of Biointerfaces

  • Szczepan ZapotocznyEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 811)

Abstract

There is an increasing demand on the development of “smart” switchable interfaces since controlling surface topography and chemical functionality on a nanometer scale is crucial for numerous biomedical applications. Those surfaces, which are based on stimuli responsive polymers (SRPs), are able to modify their interactions with cells, biomolecules responding to different physical (e.g., temperature) or chemical (e.g., pH) stimuli. Such behavior may partially mimic complex dynamic properties of natural systems that are regulated by many biological stimuli. This paper reviews major studies and applications of SRPs as biointerfaces in a form of thin polymeric films (gels) and surface tethered polymers (brushes).

Key words

Stimuli responsive polymers Polymer brush Polymer film Cell adhesion Poly(N-isopropylacrylamide) Elastin-like polypeptides 

Notes

Acknowledgments

The author acknowledges the financial support from the project operated within the Foundation for Polish Science Team Programme cofinanced by the EU European Regional Development Fund, PolyMed, TEAM/2008-2/6. Dr. Edmondo M. Benetti (ETH Zürich) is kindly acknowledged for his comments to the protocol part.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Faculty of ChemistryJagiellonian UniversityKrakowPoland

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