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Separation-Induced Depression in the Mouse

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Mood and Anxiety Related Phenotypes in Mice

Part of the book series: Neuromethods ((NM,volume 63))

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Abstract

This chapter outlines the experimental methods for inducing Depression-like behavior in mice by separating group-housed mice to individual housing. This is a model of loneliness in mice. Loneliness-induced depression is measured using the forced swim test (FST) and tail suspension test (TST). The first part of the chapter describes the methods for inducing separation-induced depression. It summarizes the experimental protocols including behavioral testing of the animals. The second part describes some of the issues to be concerned within this paradigm. An up-to-date collection of protocols and procedures for troubleshooting are provided.

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Acknowledgments

This research was funded by NSERC of Canada.

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Authors and Affiliations

  1. Psychology Department and Neuroscience Institute, Dalhousie University, Halifax, NS, Canada

    Richard E. Brown, Alison L. Martin & Rhian K. Gunn

Authors
  1. Richard E. Brown
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  2. Alison L. Martin
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  3. Rhian K. Gunn
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Corresponding author

Correspondence to Richard E. Brown .

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Editors and Affiliations

  1. School of Medicine, Department of Psychiatry, University of Maryland, W. Baltimore Street 685, Baltimore, 21201, Maryland, USA

    Todd D. Gould

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Brown, R.E., Martin, A.L., Gunn, R.K. (2011). Separation-Induced Depression in the Mouse. In: Gould, T. (eds) Mood and Anxiety Related Phenotypes in Mice. Neuromethods, vol 63. Humana Press. https://doi.org/10.1007/978-1-61779-313-4_15

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  • DOI: https://doi.org/10.1007/978-1-61779-313-4_15

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-312-7

  • Online ISBN: 978-1-61779-313-4

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