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Animal Models of Movement Disorders pp 211–238Cite as

The Use of Commissurotomy in Studies of Interhemispheric Communication

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Part of the book series: Neuromethods ((NM,volume 62))

Abstract

An overview is given of the structure and function of the mammalian cerebral commissures, with an emphasis on their role in interhemispheric communication. A major focus is placed on the use of commissurotomy as a method of selective disconnection of interhemispheric sensory-motor integration. In order for commissure section to be effective it is crucial that the sensory input is under total experimenter control. For example, in the split-brain preparation, the optic chiasma must also be sectioned as well as the corpus callosum in order to restrict the monocular visual input to a single hemisphere. Special consideration is given to differences in the commissural organisation in different species. These differences can mean that the same lesion can have different effects in various animal species. Finally, detailed surgical protocols for callosal and chiasma section are given separately for monkey, cat, rabbit, and rat. Each such surgical protocol is specifically tailored to each species’ neurosurgical vulnerabilities.

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Authors and Affiliations

  1. Departments of Psychiatry and Behavioral Science, Neuroscience and Experimental Therapeutics, and Veterinary Integrative and Biomedical Science, Texas A&M University System Health Science Center and Texas A&M University, College Station, TX, USA

    Ian Steele-Russell

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  1. Ian Steele-Russell
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Correspondence to Ian Steele-Russell .

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Editors and Affiliations

  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Steele-Russell, I. (2011). The Use of Commissurotomy in Studies of Interhemispheric Communication. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 62. Humana Press. https://doi.org/10.1007/978-1-61779-301-1_12

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  • DOI: https://doi.org/10.1007/978-1-61779-301-1_12

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  • Print ISBN: 978-1-61779-300-4

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