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Models of Rodent Cortical Traumatic Brain Injury

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Book cover Animal Models of Movement Disorders

Part of the book series: Neuromethods ((NM,volume 62))

Abstract

The absence of a pharmacological therapy that is effective in the treatment of traumatic brain injury (TBI) highlights the need for further research into the secondary mechanisms that are initiated by the traumatic event, and which determine eventual neurological outcome. Various animal models of TBI exist, with each attempting to replicate different aspects of human brain injury. If an effective pharmacological therapy is to be developed and accepted by the neurotrauma community, it is critical that there is consistency across various laboratories in how these models are applied. The present review critically analyses the benefits and pitfalls of the common rodent models of TBI that are widely used today.

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Acknowledgment

Supported, in part, by the Neurosurgical Research Foundation, Australia.

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  1. Centre for Neuroscience Research, School of Medical Sciences, University of Adelaide, Adelaide, SA, Australia

    Frances Corrigan, Jenna M. Ziebell & Robert Vink

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  1. Frances Corrigan
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  2. Jenna M. Ziebell
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Correspondence to Robert Vink .

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  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Corrigan, F., Ziebell, J.M., Vink, R. (2011). Models of Rodent Cortical Traumatic Brain Injury. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 62. Humana Press. https://doi.org/10.1007/978-1-61779-301-1_11

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