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MRI of Neurological Damage in Rats and Mice

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Animal Models of Movement Disorders

Part of the book series: Neuromethods ((NM,volume 61))

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Abstract

The present chapter introduces the potential of magnetic resonance imaging (MRI) for in vivo investigations of experimental stroke in rodents. Aspects in setting up the experiment, particular for this technique, are presented as well as considerations for the choice of anaesthesia protocol. Structural changes induced by the evolution of the pathophysiological processes are demonstrated. Furthermore, a broad range of MRI options for the investigations of functional deficits and outcome improvement are pointed out. Emphasis is set on the multimodal approach capability of MRI to obtain complementary structural, haemodynamic, metabolic and, finally also, functional information in longitudinal studies of the complex pathophysiological evolution of stroke.

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Acknowledgement

Support by the Nederlands Organisatie voor Wetenschappelijk Onderzoek and Alexander-von-Humboldt Stiftung (NWO-AvH) is gratefully acknowledged.

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Authors and Affiliations

  1. In-vivo-NMR Laboratory, Max Planck Institute for Neurological Research, Köln, Germany

    Mathias Hoehn

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  1. Mathias Hoehn
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Correspondence to Mathias Hoehn .

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Editors and Affiliations

  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Hoehn, M. (2011). MRI of Neurological Damage in Rats and Mice. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 61. Humana Press. https://doi.org/10.1007/978-1-61779-298-4_8

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  • DOI: https://doi.org/10.1007/978-1-61779-298-4_8

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-297-7

  • Online ISBN: 978-1-61779-298-4

  • eBook Packages: Springer Protocols

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