Abstract
Here, we describe the systematic mouse phenotyping approach of the German Mouse Clinic (GMC), that works as an open-access phenotyping platform, and of the European Mouse Disease Clinic, which is an EU-funded multi-centre project characterising mutants generated by the large-scale mouse mutagenesis project European Conditional Mouse Mutagenesis Program. We explain the aims and the general framework of these large-scale projects and the resulting consequences for the phenotyping strategies. Then, we focus on the description of the behavioural tests used in the GMC to detect motor and non-motor symptoms in mouse mutants that are genetic models of human movement disorders or neurodegenerative diseases.
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Acknowledgements
This work was partially supported by the Bundesministerium für Bildung und Forschung within the framework of the NGFN-Plus (FKZ: 01GS0850 and 01GS08174), the European Commission (EUMODIC: LSHG-2006-037188) and the “Helmholtz Alliance for Mental Health in an Ageing Society” (HELMA).
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Hölter, S.M., Glasl, L. (2011). High-Throughput Mouse Phenotyping. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 61. Humana Press. https://doi.org/10.1007/978-1-61779-298-4_7
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DOI: https://doi.org/10.1007/978-1-61779-298-4_7
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