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Animal Models of Movement Disorders pp 109–133Cite as

High-Throughput Mouse Phenotyping

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Part of the book series: Neuromethods ((NM,volume 61))

Abstract

Here, we describe the systematic mouse phenotyping approach of the German Mouse Clinic (GMC), that works as an open-access phenotyping platform, and of the European Mouse Disease Clinic, which is an EU-funded multi-centre project characterising mutants generated by the large-scale mouse mutagenesis project European Conditional Mouse Mutagenesis Program. We explain the aims and the general framework of these large-scale projects and the resulting consequences for the phenotyping strategies. Then, we focus on the description of the behavioural tests used in the GMC to detect motor and non-motor symptoms in mouse mutants that are genetic models of human movement disorders or neurodegenerative diseases.

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Acknowledgements

This work was partially supported by the Bundesministerium für Bildung und Forschung within the framework of the NGFN-Plus (FKZ: 01GS0850 and 01GS08174), the European Commission (EUMODIC: LSHG-2006-037188) and the “Helmholtz Alliance for Mental Health in an Ageing Society” (HELMA).

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Authors and Affiliations

  1. Helmholtz Zentrum München, Institute of Developmental Genetics, Technical University Munich, Neuherberg, Germany

    Sabine M. Hölter & Lisa Glasl

Authors
  1. Sabine M. Hölter
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  2. Lisa Glasl
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Correspondence to Sabine M. Hölter .

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Editors and Affiliations

  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Hölter, S.M., Glasl, L. (2011). High-Throughput Mouse Phenotyping. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 61. Humana Press. https://doi.org/10.1007/978-1-61779-298-4_7

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  • DOI: https://doi.org/10.1007/978-1-61779-298-4_7

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-297-7

  • Online ISBN: 978-1-61779-298-4

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