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Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke

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Animal Models of Movement Disorders

Part of the book series: Neuromethods ((NM,volume 61))

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Abstract

To maximize the success of any translational research endeavor, sensitive and reliable behavioral outcome measures in valid animal models are essential. A common goal of preclinical studies in both Parkinson’s disease and stroke is to reduce or reverse sensorimotor impairments associated with damage to the striatum and sensorimotor cortex. Here, we describe several behavioral tests of sensorimotor function that have been shown to be sensitive to varying degrees of nigrostriatal and cortical damage in both rats and mice and are highly useful for preclinical studies of potential therapeutics.

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Author information

Authors and Affiliations

  1. Departments of Psychology and Neurology, University of Cincinnati, Cincinnati, IL, USA

    Sheila M. Fleming

  2. Department of Psychology, University of Texas at Austin, Austin, TX, USA

    Timothy Schallert

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  1. Sheila M. Fleming
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  2. Timothy Schallert
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Correspondence to Timothy Schallert .

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Editors and Affiliations

  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Fleming, S.M., Schallert, T. (2011). Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 61. Humana Press. https://doi.org/10.1007/978-1-61779-298-4_17

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  • DOI: https://doi.org/10.1007/978-1-61779-298-4_17

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-297-7

  • Online ISBN: 978-1-61779-298-4

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