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Basic Contrast Mechanisms

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Book cover In vivo NMR Imaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 771))

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Abstract

This chapter provides an overview of how contrast in MR images can be achieved. The physical origin of the most basic contrast mechanisms is briefly explained and experiments to exploit these are discussed. Furthermore, the concept of using exogenous contrast agents is introduced.

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References

  1. Kuo, Y.-T., Herlihy, A. H. (2008) Optimization of MRI contrast for pre-clinical studies at high magnetic field. In Webb, G. A. (ed.), Modern Magnetic Resonance, Vol. I, pp. 759–768. Springer, Dordrecht.

    Google Scholar 

  2. de Graaf, R. A. (2007) In vivo NMR spectroscopy – dynamic aspects, Chapter 3. In de Graaf, R. A. (ed.), In Vivo NMR Spectroscopy, Principles and Techniques. Wiley, West Sussex.

    Chapter  Google Scholar 

  3. Neuberger, T., Webb, A. (2009) Radiofrequency coils for magnetic resonance microscopy. NMR Biomed. 22, 975–981.

    Google Scholar 

  4. Baltes, C., Radzwill, N., Bosshard, S., Marek, D., Rudin, M. (2009) Micro MRI of the mouse brain using a novel 400 MHz cryogenic quadrature RF probe. NMR Biomed. 22, 834–842.

    Article  PubMed  Google Scholar 

  5. Callaghan, P. T. (1991) Principles of Nuclear Magnetic Resonance Microscopy. Clarendon Press, Oxford.

    Google Scholar 

  6. Krause, W. (ed.). (2002) Contrast Agents I – Magnetic Resonance Imaging. Springer, Berlin.

    Google Scholar 

  7. Caravan, P. (2006) Strategies for increasing the sensitivity of gadolinium based contrast agents. Chem. Soc. Rev. 35, 512–523.

    Article  PubMed  CAS  Google Scholar 

  8. Ugurbil, K., Adriany, K., Akgün, C., Andersen, P., Chen, W., Garwood, M., Gruetter, R., Henry, P.-G., Marjanska, M., Moeller, S., Van de Moortele, P.-F., Prüssmann, K., Tkac, I., Vaughan, J. T., Wiesinger, F., Yacoub, E., Zhu, X.-H. (2006) High magnetic fields for imaging cerebral morphology, function, and biochemistry. In Robitaille, P.-M., Berliner, L. (eds.), Ultra High Field Magnetic Resonance Imaging, pp. 285–343. Springer, New York, NY.

    Google Scholar 

  9. Lei, H., Zhu, X.-H., Zhang, X.-L., Ugurbil, K., Chen, W. (2003) In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: an initial experience Magn. Reson. Med. 49, 199.

    Article  PubMed  CAS  Google Scholar 

  10. Reiser, M. F., Semmler, W., Hricak, H. (eds.). (2008) Magnetic Resonance Tomography. Springer, Berlin.

    Google Scholar 

  11. Huppertz, A., Zech, C. J. (2008) Contrast agents. In Reiser, M. F., Semmler, W., Hricak, H. (eds.), Magnetic Resonance Tomography, pp. 92–113. Springer, Berlin.

    Google Scholar 

  12. Burtea, C., Laurent, S., Van der Elst, L., Muller, R. N. (2008) Contrast agents: Magnetic resonance. In Semmler, W., Schwaiger, M. (eds.), Molecular Imaging I, Handbook of Experimental Pharmacology 185/I, pp. 135–165. Springer, Berlin.

    Google Scholar 

  13. Tóth, E., Helm, L., Merbach, A. E. (2002) Relaxivity of MRI contrast agents. In Krause, W. (ed.), Contrast Agents I – Magnetic Resonance Imaging, pp. 61–101. Springer, Berlin.

    Google Scholar 

  14. Corot, C., Port, M., Guilbert, I., Robert, P., Raynal, I., Robic, C., Raynaud, J.-S., Prigent, P., Dencausse, A., Idée, J.-M. (2007) Superparamagnetic contrast agents. In Modo, M. M. J., Bulte, J. W. M. (eds.), Molecular and Cellular MR Imaging, pp. 59–83. CRC Press, Taylor & Francis Group, Boca Raton.

    Google Scholar 

  15. Weissleder, R., Moore, R., Mahmood, U., Bhorade, R., Benveniste, H., Chiocca, E. A., Basilion, J. P. (2000) In vivo magnetic resonance imaging of transgene expression. Nat. Med. 6, 351.

    Article  PubMed  CAS  Google Scholar 

  16. Bergin, C. J., Pauly, J. M., Macovski, A. (1991) Lung parenchyma: projection, reconstruction MR imaging. Radiology 179, 777–781.

    PubMed  CAS  Google Scholar 

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Correspondence to Leif Schröder .

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Schröder, L., Faber, C. (2011). Basic Contrast Mechanisms. In: Schröder, L., Faber, C. (eds) In vivo NMR Imaging. Methods in Molecular Biology, vol 771. Humana Press. https://doi.org/10.1007/978-1-61779-219-9_3

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  • DOI: https://doi.org/10.1007/978-1-61779-219-9_3

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-218-2

  • Online ISBN: 978-1-61779-219-9

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