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Diverse Small Non-coding RNAs in RNA Interference Pathways

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Therapeutic Oligonucleotides

Part of the book series: Methods in Molecular Biology ((MIMB,volume 764))

Abstract

Large numbers of diverse small non-coding RNAs have been discovered and characterized in eukaryotic RNA interference pathways. These small RNAs have distinctive characteristics and are associated with Argonaute family proteins to regulate gene expression and genomes at various levels. These small RNAs include the Dicer-dependent group such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), and the Dicer-independent group such as Piwi-interacting RNAs (piRNAs). This review summarizes the various classes of eukaryotic small RNAs and the general knowledge of their characteristics, biogenesis, and functions, with emphasis on some of the recently identified small RNAs.

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Acknowledgement

This work is supported by funds from the National Institute of Health and Welch Foundation (I-1560) to Y. Liu.

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Authors and Affiliations

  1. Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA

    Liande Li & Yi Liu

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  1. Liande Li
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  2. Yi Liu
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Correspondence to Yi Liu .

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Editors and Affiliations

  1. Dept. Chemistry, Worcester State College, Chandler St. 486, Worcester, 01602, Massachusetts, USA

    John Goodchild

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Li, L., Liu, Y. (2011). Diverse Small Non-coding RNAs in RNA Interference Pathways. In: Goodchild, J. (eds) Therapeutic Oligonucleotides. Methods in Molecular Biology, vol 764. Humana Press. https://doi.org/10.1007/978-1-61779-188-8_11

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  • DOI: https://doi.org/10.1007/978-1-61779-188-8_11

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-187-1

  • Online ISBN: 978-1-61779-188-8

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