Abstract
Metastatic spread of cancer is the major reason for patient mortality in human breast cancer. We examined expression of claudin-16 in human breast cells and tissues to identify a possible link between expression and aggressiveness in cells and between claudin-16 levels and patient prognosis. Forced expression of claudin-16 in breast cancer cells resulted in a less aggressive phenotype and reduced in vivo tumour volume. Claudin-16 expression was reduced in human breast cancer, particularly in patients with aggressive tumours and high mortality (Martin et al. J Cell Biochem 105:41–52,2008). This suggests that claudin-16 plays a role beyond that of an initial metastasis repressor in this cancer type.
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References
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Martin, T.A., Jiang, W.G. (2011). Claudin-16/Paracellin-1, Cloning, Expression, and Its Role in Tight Junction Functions in Cancer and Endothelial Cells. In: Turksen, K. (eds) Claudins. Methods in Molecular Biology, vol 762. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-185-7_28
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DOI: https://doi.org/10.1007/978-1-61779-185-7_28
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Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-184-0
Online ISBN: 978-1-61779-185-7
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