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Methods for the Discovery and Characterization of G Protein-Coupled Receptors pp 347–358Cite as

Detecting the Role of Arrestins in G Protein-Coupled Receptor Regulation

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Part of the book series: Neuromethods ((NM,volume 60))

Abstract

G protein-coupled receptors (GPCRs) are the major sites of actions for the body’s endogenous hormones and neurotransmitters which make them ideal targets for pharmaceutical development with the goal of either mimicking the normal transmitter response or tempering it. In recent years, targeting GPCRs has become more complicated as we realize that drug action at receptors is “context dependent” such that activation and inhibition is limited to the response evaluated and agonist and antagonist become terms that reflect a particular condition of the experimental or physiological output. Therefore, the composition of the receptor’s immediate environment may determine activation profiles as posttranslational modifications of the receptor or of the binding partners can ultimately lead to regulation of the responsiveness of the receptor.

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Authors and Affiliations

  1. Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, USA

    Laura M. Bohn

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  1. Laura M. Bohn
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  2. Patricia H. McDonald
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Correspondence to Laura M. Bohn .

Editor information

Editors and Affiliations

  1. Center for Health Sciences, College of Osteopathic Medicine, Oklahoma State University, W. 17th Street 1111, Tulsa, 74107, Oklahoma, USA

    Craig W. Stevens

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Bohn, L.M., McDonald, P.H. (2011). Detecting the Role of Arrestins in G Protein-Coupled Receptor Regulation. In: Stevens, C. (eds) Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Neuromethods, vol 60. Humana Press. https://doi.org/10.1007/978-1-61779-179-6_17

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  • DOI: https://doi.org/10.1007/978-1-61779-179-6_17

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