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Multiresidue Analysis of Antibiotics in Food of Animal Origin Using Liquid Chromatography–Mass Spectrometry

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Mass Spectrometry in Food Safety

Part of the book series: Methods in Molecular Biology ((MIMB,volume 747))

Abstract

Antibiotics are the most important drugs administered in veterinary medicine. Their use in food-producing animals may result in antibiotic residues in edible tissues, which are monitored to protect human and animal health, support the enforcement of regulations, provide toxicological assessment data, and resolve international trade issues. This chapter provides basic characterization of the most important classes of antibiotics used in food-producing animals (aminoglycosides, amphenicols, β-lactams, macrolides and lincosamides, nitrofurans, quinolones, sulfonamides, and tetracyclines), along with examples of practical liquid chromatographic-(tandem) mass spectrometric methods for analysis of their residues in food matrices of animal origin. The focus is on multiresidue methods that are favored by regulatory and other food testing laboratories for their ability to analyze residues of multiple compounds in a time- and cost-effective way.

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  1. Greenfield Laboratories, Nutritional Chemistry and Food Safety, Covance Laboratories, Inc., Greenfield, IN, USA

    Katerina Mastovska

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  1. Katerina Mastovska
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  1. , Food Safety, Agilent Technologies, Inc., Centerville Rd. 2850, Wilmington, 19808, Delaware, USA

    Jerry Zweigenbaum

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Mastovska, K. (2011). Multiresidue Analysis of Antibiotics in Food of Animal Origin Using Liquid Chromatography–Mass Spectrometry. In: Zweigenbaum, J. (eds) Mass Spectrometry in Food Safety. Methods in Molecular Biology, vol 747. Humana Press. https://doi.org/10.1007/978-1-61779-136-9_12

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  • DOI: https://doi.org/10.1007/978-1-61779-136-9_12

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-135-2

  • Online ISBN: 978-1-61779-136-9

  • eBook Packages: Springer Protocols

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