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Chemical Modifications of Atomic Force Microscopy Tips

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Atomic Force Microscopy in Biomedical Research

Part of the book series: Methods in Molecular Biology ((MIMB,volume 736))

Abstract

Atomic force microscopy (AFM) works by scanning a very tiny tip over a surface with great precision. The microscope tips can be chemically functionalized to improve the images obtained. Well-defined chemical functionalization of AFM tips is especially important for experiments, such as chemical force microscopy and single molecule recognition force microscopy, to examine specific interactions at the single molecular level. In this chapter, we present an overview of chemical modifications of tips that have been reported to date with regards to the proper fixation of probe molecules, focusing particularly on chemical procedures developed to anchor biological molecules on AFM tips.

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Authors and Affiliations

  1. Département de chimie, Université Laval, Quebec, QC, Canada

    Normand Voyer

Authors
  1. Régis Barattin
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  2. Normand Voyer
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Correspondence to Normand Voyer .

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Editors and Affiliations

  1. School of Medicine, Department of Pharmacology, University of Milan, Via Vanvitelli 32, Milano, 20129, Italy

    Pier Carlo Braga

  2. , Robotics, Brain & Cognitive Sciences, Italian Institute of Technology, Via Morego 30, Genova, 16163, Italy

    Davide Ricci

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Barattin, R., Voyer, N. (2011). Chemical Modifications of Atomic Force Microscopy Tips. In: Braga, P., Ricci, D. (eds) Atomic Force Microscopy in Biomedical Research. Methods in Molecular Biology, vol 736. Humana Press. https://doi.org/10.1007/978-1-61779-105-5_28

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  • DOI: https://doi.org/10.1007/978-1-61779-105-5_28

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