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Identification, Chemical Synthesis, and Biological Functions of Unusual Polyamines Produced by Extreme Thermophiles

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Book cover Polyamines

Part of the book series: Methods in Molecular Biology ((MIMB,volume 720))

Abstract

Unusual long polyamines such as caldopentamine and caldohexamine, and branched polyamines such as tetrakis(3-aminopropyl)ammonium and N 4-aminopropylspermidine were often found in cells of extreme thermophiles and hyperthermophiles belonging to both Bacteria and Archaea domains. Some of these unusual polyamines are essential for life at extreme temperatures. In some cases, the unusual polyamines also exist in cells of nonthermophilic organisms and play important physiological roles under normal conditions. Methods for chromatographic analysis, isolation, and chemical syntheses of unusual polyamines as well as experimental methods for measuring their physiological roles are discussed. Especially, many newly improved methods for chemical syntheses are presented in this article.

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Acknowledgements

Studies cited in this article were done by many former colleagues in our laboratories in University of Tokyo, Mitsubishi-Kasei Institute of Life Sciences, Tokyo Institute of Technology, Tokyo University of Pharmacy and Life Science, and the Institute of Environmental Microbiology, Kyowa-kako Company. Especially the authors are grateful to Drs. Mio Ohnuma, Taketoshi Uzawa, Yoshiko Ohno-Iwashita, and Nobuko Hamasaki-Katagiri.

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Authors and Affiliations

  1. Institute of Environmental Microbiology, Kyowa-kako Co., Machida, Tokyo, Japan

    Tairo Oshima & Toshiyuki Moriya

  2. Department of Molecular Biology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan

    Toshiyuki Moriya

  3. Faculty of Pharmacy, Chiba Institute of Science, Choshi, Chiba, Japan

    Yusuke Terui

Authors
  1. Tairo Oshima
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  2. Toshiyuki Moriya
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  3. Yusuke Terui
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Editors and Affiliations

  1. College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, University Drive 500, Hershey, 17033-0850, Pennsylvania, USA

    Anthony E. Pegg

  2. School of Medicine, Sidney Kimmel Comprehensive, Johns Hopkins University, Orleans St. 1650, Baltimore, 21231, Maryland, USA

    Robert A. Casero, Jr.

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Oshima, T., Moriya, T., Terui, Y. (2011). Identification, Chemical Synthesis, and Biological Functions of Unusual Polyamines Produced by Extreme Thermophiles. In: Pegg, A., Casero, Jr., R. (eds) Polyamines. Methods in Molecular Biology, vol 720. Humana Press. https://doi.org/10.1007/978-1-61779-034-8_5

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  • DOI: https://doi.org/10.1007/978-1-61779-034-8_5

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-033-1

  • Online ISBN: 978-1-61779-034-8

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