Current Status of the Polyamine Research Field

  • Anthony E. Pegg
  • Robert A. CaseroJr.
Part of the Methods in Molecular Biology book series (MIMB, volume 720)


This chapter provides an overview of the polyamine field and introduces the 32 other chapters that make up this volume. These chapters provide a wide range of methods, advice, and background relevant to studies of the function of polyamines, the regulation of their content, their role in disease, and the therapeutic potential of drugs targeting polyamine content and function. The methodology provided in this new volume will enable laboratories already working in this area to expand their experimental techniques and facilitate the entry of additional workers into this rapidly expanding field.

Key words

Putrescine Spermidine Spermine Hypusine Antizyme Polyamine transport 



Research in the authors’ laboratories on polyamines has been supported by NIH (CA-018138 and GM-26290 to AEP; CA-51085 and CA-98454 to RAC) and by grants from Komen for the Cure KG08923, and the Samuel Waxman Cancer Research Foundation (to RAC).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Anthony E. Pegg
    • 1
  • Robert A. CaseroJr.
    • 2
  1. 1.College of Medicine, Milton S. Hershey Medical CenterPennsylvania State UniversityHersheyUSA
  2. 2.School of Medicine, Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins UniversityBaltimoreUSA

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